Engagement of CD160 Receptor by HLA-C Is a Triggering Mechanism Used by Circulating Natural Killer (NK) Cells to Mediate Cytotoxicity

Circulating human natural killer (NK) lymphocytes have been functionally defined by their ability to exert cytotoxic activity against MHC class I-negative target cell lines, including K562. Therefore, it was proposed that NK cells recognized the "missing self." We show here that the Ig-lik...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-12, Vol.99 (26), p.16963-16968
Hauptverfasser:	Le Bouteiller, Philippe, Barakonyi, Aliz, Giustiniani, Jérome, Lenfant, Françoise, Marie-Cardine, Anne, Aguerre-Girr, Maryse, Rabot, Magali, Hilgert, Ivan, Mami-Chouaib, Fathia, Tabiasco, Julie, Boumsell, Laurence, Bensussan, Armand
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - physiology Biological Sciences Cell lines Cells Cytometry Cytotoxicity Cytotoxicity, Immunologic GPI-Linked Proteins HLA C antigens HLA-C Antigens - physiology Humans Immunology Interleukin-2 - physiology K562 cells Killer Cells, Natural - immunology Lectins, C-Type - physiology Ligands Membrane Proteins - physiology Molecules Natural killer cells NK Cell Lectin-Like Receptor Subfamily D Receptors Receptors, Immunologic - physiology Receptors, KIR Receptors, KIR2DL3 T lymphocytes Toxicity
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