The Brucellasuis genome reveals fundamental similarities between animal and plant pathogens and symbionts
The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis , was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between th...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2002-10, Vol.99 (20), p.13148 |
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| creator | Ian T. Paulsen Rekha Seshadri Karen E. Nelson Jonathan A. Eisen John F. Heidelberg Timothy D. Read Robert J. Dodson Lowell Umayam Lauren M. Brinkac Maureen J. Beanan Sean C. Daugherty Robert T. Deboy A. Scott Durkin James F. Kolonay Ramana Madupu William C. Nelson Bola Ayodeji Margaret Kraul Jyoti Shetty Joel Malek Susan E. Van Aken Steven Riedmuller Herve Tettelin Steven R. Gill Owen White Steven L. Salzberg David L. Hoover Luther E. Lindler Shirley M. Halling Stephen M. Boyle Claire M. Fraser |
| description | The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis , was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified. |
| doi_str_mv | 10.1073/pnas.192319099 |
| format | Article |
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| title | The Brucellasuis genome reveals fundamental similarities between animal and plant pathogens and symbionts |
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