Myc Represses the p21(WAF1/CIP1)Promoter and Interacts with Sp1/Sp3

The cyclin-dependent kinase inhibitor p21(WAF1/CIP1)inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G1cell cycle arrest. Recent studies showed that Myc can repre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-04, Vol.98 (8), p.4510-4515
Hauptverfasser:	Gartel, Andrei L., Ye, Xin, Goufman, Eugene, Shianov, Pavel, Hay, Nissim, Najmabadi, Feridoon, Tyner, Angela L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Base Sequence Biological Sciences Caco 2 cells Cell cycle Cell growth Cell Line, Transformed Cell lines Cellular biology Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics DNA Primers DNA-Binding Proteins - metabolism Genes Genetics Histones Humans Mice Molecular biology Promoter regions Promoter Regions, Genetic Protein Binding Proteins Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins c-myc - physiology Repression Reverse Transcriptase Polymerase Chain Reaction Sp1 Transcription Factor - metabolism Sp3 Transcription Factor Transcription Factors - metabolism Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!