Gene Program for Cardiac Cell Survival Induced by Transient Ischemia in Conscious Pigs

Therapy for ischemic heart disease has been directed traditionally at limiting cell necrosis. We determined by genome profiling whether ischemic myocardium can trigger a genetic program promoting cardiac cell survival, which would be a novel and potentially equally important mechanism of salvage. Al...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-07, Vol.98 (16), p.9336-9341
Hauptverfasser:	Depre, Christophe, Tomlinson, James E., Kudej, Raymond K., Gaussin, Vinciane, Thompson, Erika, Kim, Song-Jung, Vatner, Dorothy E., Topper, James N., Vatner, Stephen F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological Sciences Cardiovascular disease cardiovascular diseases Cell growth Cell Survival - genetics Cells Cytoprotection DNA, Complementary Female Gene expression Gene Expression Profiling Genes Genomics Heart Hogs In Situ Hybridization Ischemia Myocardial Ischemia - pathology Myocardial reperfusion Myocardial stunning Myocardium Myocardium - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Swine
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