Developmental Plasticity of CNS Microglia

Microglia arise from CD45+bone marrow precursors that colonize the fetal brain and play a key role in central nervous system inflammatory conditions. We report that parenchymal microglia are uncommitted myeloid progenitors of immature dendritic cells and macrophages by several criteria, including su...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-05, Vol.98 (11), p.6295-6300
Hauptverfasser:	Santambrogio, L., Belyanskaya, S. L., Fischer, F. R., Cipriani, B., Brosnan, C. F., Ricciardi-Castagnoli, P., Stern, L. J., Strominger, J. L., Riese, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B lymphocytes Biological Sciences Cathepsins - genetics Cathepsins - immunology Cell Differentiation Cell lines Cells Cells, Cultured Central nervous system Central Nervous System - cytology Central Nervous System - immunology Cultured cells Delta cells Dendritic Cells - immunology Epithelial cells Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - immunology Histocompatibility Antigens Class II - immunology Immunology Interferon-gamma - immunology Interferon-gamma - pharmacology Macrophages Macrophages - immunology Membrane Proteins - biosynthesis Mice Microglia Microglia - cytology Microglia - drug effects Microglia - immunology Molecules Nervous system Neuronal Plasticity - immunology Proteins Stem Cell Factor - biosynthesis stem cell factor receptors T lymphocytes
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