The Immunosuppressive Macrolide RAD Inhibits Growth of Human Epstein-Barr Virus-Transformed B Lymphocytes in vitro and in vivo: A Potential Approach to Prevention and Treatment of Posttransplant Lymphoproliferative Disorders

Whereas the standard immunosuppressive agents foster development of posttransplant lymphoproliferative disorders (PTLDs), the impact of RAD, a macrolide with potent immunosuppressive properties, and other immunosuppressive macrolides on these disorders remains undetermined. We found that RAD had a p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-04, Vol.97 (8), p.4285-4290
Hauptverfasser:	Majewski, Miroslaw, Korecka, Magdalena, Kossev, Plamen, Li, Shiyong, Goldman, June, Moore, Jonni, Silberstein, Leslie E., Nowell, Peter C., Schuler, Walter, Shaw, Leslie M., Wasik, Mariusz A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects B cell lymphoma B lymphocytes Biological Sciences Cell Cycle - drug effects Cell Division - drug effects Cell growth Cell Line, Transformed Cell lines Dosage Epstein-Barr virus Everolimus Herpesvirus 4, Human - drug effects Humans Immunosuppressants Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use In Vitro Techniques Lymphoma Lymphoproliferative Disorders - drug therapy Lymphoproliferative Disorders - prevention & control macrolide antibiotics Mice Mice, Inbred ICR Mice, SCID Neoplasm Transplantation Sirolimus - analogs & derivatives Sirolimus - pharmacology Sirolimus - therapeutic use T lymphocytes Transplantation - adverse effects Tumor cell line Tumors
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