Recombinant Bacillus Calmette-Guerin (BCG) Vaccines Expressing the Mycobacterium tuberculosis 30-kDa Major Secretory Protein Induce Greater Protective Immunity against Tuberculosis than Conventional BCG Vaccines in a Highly Susceptible Animal Model

Tuberculosis (TB) continues to ravage humanity, causing 2 million deaths per year. A vaccine against TB more potent than the current live vaccine, bacillus Calmette-Guerin (BCG), is desperately needed. Using two commercially available strains of BCG as host strains, BCG Connaught and Tice, we have c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-12, Vol.97 (25), p.13853-13858
Hauptverfasser:	Horwitz, M A, Harth, G, Dillon, B J, Maslesa-Galic', S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bacillus calmette guerin vaccine BCG Vaccine - immunology Biological Sciences Disease models Disease Models, Animal Guinea Pigs Hypersensitivity, Delayed - immunology Immunity Immunization Lungs Male Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Skin - immunology Spleen Tuberculosis - immunology Tuberculosis vaccine Vaccination Vaccines, Synthetic - immunology
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