Regulation of the Antioxidant Response Element by Protein Kinase C-Mediated Phosphorylation of NF-E2-Related Factor 2

A coordinated cellular response to oxidative stress occurs in part through transcriptional regulation via a cis-acting sequence known as the antioxidant response element (ARE). NF-E2-related factor 2 (Nrf2), a member of the Cap'n'Collar family of basic region-leucine zipper (bZIP) transcri...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-11, Vol.97 (23), p.12475-12480
Hauptverfasser:	H.-C. Huang, Nguyen, Truyen, Pickett, Cecil B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antioxidants Antioxidants - metabolism Antioxidants - pharmacology beta-Naphthoflavone - metabolism beta-Naphthoflavone - pharmacology Biochemistry Biological Sciences Cells DNA-Binding Proteins - metabolism Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Gene expression Gene expression regulation Hep G2 cells Humans Hydroquinones - metabolism Hydroquinones - pharmacology Indoles - pharmacology Leucine Zippers NF-E2-Related Factor 2 Oxidative Stress Phosphorylation Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Proteins Pyrroles - pharmacology Rats Response Elements Signal Transduction Staurosporine - pharmacology Tetradecanoylphorbol Acetate - metabolism Tetradecanoylphorbol Acetate - pharmacology Trans-Activators - metabolism Transcription factors Tumor Cells, Cultured
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