Bruchins: Insect-Derived Plant Regulators That Stimulate Neoplasm Formation
Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larvel entry into the...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (11), p.6218-6223 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Doss, Robert P. Oliver, James E. Proebsting, William M. Potter, Sandra W. Kuy, SreyReath Clement, Stephen L. Williamson, R. Thomas Carney, John R. DeVilbiss, E. David |
| description | Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larvel entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain α,ω -diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants. |
| doi_str_mv | 10.1073/pnas.110054697 |
| format | Article |
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Thomas ; Carney, John R. ; DeVilbiss, E. David</creator><creatorcontrib>Doss, Robert P. ; Oliver, James E. ; Proebsting, William M. ; Potter, Sandra W. ; Kuy, SreyReath ; Clement, Stephen L. ; Williamson, R. Thomas ; Carney, John R. ; DeVilbiss, E. David</creatorcontrib><description>Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larvel entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain α,ω -diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.110054697</identifier><identifier>PMID: 10811915</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biological Sciences ; Botany ; Bruchidae ; Bruchus pisorum ; Cell Division ; Chemicals ; Coleoptera - physiology ; Esters ; Ethers ; Fatty Alcohols - chemistry ; Fatty Alcohols - isolation & purification ; Fatty Alcohols - metabolism ; Fatty Alcohols - toxicity ; Female ; Female animals ; Host-Parasite Interactions ; Hydrolysis ; Immunity, Innate ; Insect eggs ; Insects ; Molecular Structure ; Neoplasia ; Oviposition ; Peas ; Pisum sativum ; Pisum sativum - physiology ; Plant Tumors - chemically induced ; Plant Tumors - etiology ; Plants ; Propionates - chemistry ; Propionates - isolation & purification ; Propionates - metabolism ; Propionates - toxicity ; Vegetables ; Weevils</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (11), p.6218-6223</ispartof><rights>Copyright 1993-2000 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences May 23, 2000</rights><rights>Copyright © The National Academy of Sciences 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-dd2006093d3cd86d7b145cd241f0c2c7b882bb042d4b75d81e6b836459c3f8e63</citedby><cites>FETCH-LOGICAL-c517t-dd2006093d3cd86d7b145cd241f0c2c7b882bb042d4b75d81e6b836459c3f8e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/97/11.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/122608$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/122608$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10811915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doss, Robert P.</creatorcontrib><creatorcontrib>Oliver, James E.</creatorcontrib><creatorcontrib>Proebsting, William M.</creatorcontrib><creatorcontrib>Potter, Sandra W.</creatorcontrib><creatorcontrib>Kuy, SreyReath</creatorcontrib><creatorcontrib>Clement, Stephen L.</creatorcontrib><creatorcontrib>Williamson, R. Thomas</creatorcontrib><creatorcontrib>Carney, John R.</creatorcontrib><creatorcontrib>DeVilbiss, E. David</creatorcontrib><title>Bruchins: Insect-Derived Plant Regulators That Stimulate Neoplasm Formation</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larvel entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain α,ω -diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.</description><subject>Animals</subject><subject>Biological Sciences</subject><subject>Botany</subject><subject>Bruchidae</subject><subject>Bruchus pisorum</subject><subject>Cell Division</subject><subject>Chemicals</subject><subject>Coleoptera - physiology</subject><subject>Esters</subject><subject>Ethers</subject><subject>Fatty Alcohols - chemistry</subject><subject>Fatty Alcohols - isolation & purification</subject><subject>Fatty Alcohols - metabolism</subject><subject>Fatty Alcohols - toxicity</subject><subject>Female</subject><subject>Female animals</subject><subject>Host-Parasite Interactions</subject><subject>Hydrolysis</subject><subject>Immunity, Innate</subject><subject>Insect eggs</subject><subject>Insects</subject><subject>Molecular Structure</subject><subject>Neoplasia</subject><subject>Oviposition</subject><subject>Peas</subject><subject>Pisum sativum</subject><subject>Pisum sativum - physiology</subject><subject>Plant Tumors - chemically induced</subject><subject>Plant Tumors - etiology</subject><subject>Plants</subject><subject>Propionates - chemistry</subject><subject>Propionates - isolation & purification</subject><subject>Propionates - metabolism</subject><subject>Propionates - toxicity</subject><subject>Vegetables</subject><subject>Weevils</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1v1DAQxS1ERbeFKxckFHEopywzjh07iAsU-iEqQFDOlmM73aySeLGdCv57Eu3SLoiTpZnfe36jR8hThCWCKF5tBh2XiACclZV4QBYIFeYlq-AhWQBQkUtG2SE5inENABWX8IgcIkjECvmCfHwXRrNqh_g6uxyiMyl_70J762z2pdNDyr66m7HTyYeYXa90yr6ltp8HLvvk_KbTsc_OfOh1av3wmBw0uovuye49Jt_PPlyfXuRXn88vT99e5YajSLm1FKCEqrCFsbK0okbGjaUMGzDUiFpKWtfAqGW14FaiK2tZlIxXpmikK4tj8mbruxnr3lnjhhR0pzah7XX4pbxu1d-boV2pG3-rUHLJJ_nJTh78j9HFpPo2GtdN9zo_RoWCU8k5ncAX_4BrP4ZhOk1RwEJwVs1hllvIBB9jcM1dDgQ1V6TmitRdRZPg-X76PXzbyQS83AGz8M-6EpOHKilK1Yxdl9zPtGf1f3ICnm2BdZwqvP-K0hJk8RsaLK5O</recordid><startdate>20000523</startdate><enddate>20000523</enddate><creator>Doss, Robert P.</creator><creator>Oliver, James E.</creator><creator>Proebsting, William M.</creator><creator>Potter, Sandra W.</creator><creator>Kuy, SreyReath</creator><creator>Clement, Stephen L.</creator><creator>Williamson, R. 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Thomas</au><au>Carney, John R.</au><au>DeVilbiss, E. David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bruchins: Insect-Derived Plant Regulators That Stimulate Neoplasm Formation</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2000-05-23</date><risdate>2000</risdate><volume>97</volume><issue>11</issue><spage>6218</spage><epage>6223</epage><pages>6218-6223</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larvel entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain α,ω -diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>10811915</pmid><doi>10.1073/pnas.110054697</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological Sciences Botany Bruchidae Bruchus pisorum Cell Division Chemicals Coleoptera - physiology Esters Ethers Fatty Alcohols - chemistry Fatty Alcohols - isolation & purification Fatty Alcohols - metabolism Fatty Alcohols - toxicity Female Female animals Host-Parasite Interactions Hydrolysis Immunity, Innate Insect eggs Insects Molecular Structure Neoplasia Oviposition Peas Pisum sativum Pisum sativum - physiology Plant Tumors - chemically induced Plant Tumors - etiology Plants Propionates - chemistry Propionates - isolation & purification Propionates - metabolism Propionates - toxicity Vegetables Weevils |
| title | Bruchins: Insect-Derived Plant Regulators That Stimulate Neoplasm Formation |
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