TOXCAT: A Measure of Transmembrane Helix Association in a Biological Membrane

The noncovalent association of transmembrane α -helices is a fundamental event in the folding of helical membrane proteins. In this work, a system (TOXCAT) is developed for the study of transmembrane helix-helix oligomerization in a natural membrane environment. This assay uses a chimeric construct...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-02, Vol.96 (3), p.863-868
Hauptverfasser:	Russ, William P., Engelman, Donald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette Transporters Bacterial Proteins Base Sequence Biochemistry Biological Sciences Carrier Proteins - genetics Cell Membrane - metabolism Cell Membrane - ultrastructure Chimeras Chloramphenicol O-Acetyltransferase - chemistry Chloramphenicol O-Acetyltransferase - genetics Chloramphenicol O-Acetyltransferase - metabolism Detergents Dimerization Dimers DNA Primers DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins Gene Library Genes, Reporter Genetic Complementation Test Genetic mutation Libraries Macromolecular Substances Maltose-Binding Proteins Membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Micelles Models, Molecular Molecular Sequence Data Monosaccharide Transport Proteins P branes Periplasmic Binding Proteins Protein Folding Protein Structure, Secondary Proteins Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Spheroplasts - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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