mechanism of paraquat toxicity involving nitric oxide synthase

Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide. NO synthase (NOS) has been shown to participate in PQ-induced lung injury. Current theory holds that NO reacts with superoxide gen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-10, Vol.96 (22), p.12760-12765
Hauptverfasser:	Day, B.J, Patel, M, Chang, L.Y, Stamler, J.S
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid derivatives Animals aorta Biological Sciences Cell Line Cell Survival - drug effects Cellular biology Cultured cells Cytotoxicity Endothelial cells endothelium endothelium derived relaxation factors Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology enzyme activity enzyme inhibitors Enzyme Inhibitors - pharmacology Enzymes In Vitro Techniques inhibition Macrophages Macrophages - cytology Macrophages - drug effects Male NADH, NADPH Oxidoreductases - metabolism neurons Nitrates nitric oxide Nitric Oxide - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Nitrites Nitrogen nitrotyrosine Oxidation oxygenases paraquat Paraquat - toxicity paraquat diaphorase polypeptides Rabbits rats Superoxides Toxicity Transcriptional regulatory elements tyrosine
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