XK469, a Selective Topoisomerase IIβ Poison

XK469 (NSC 697887) is a synthetic quinoxaline phenoxypropionic acid derivative that possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. We report here that XK469 and its S(-) and R(+)-isomers induce reversible protein-DNA crosslinks in mammalian cells. Un...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-10, Vol.96 (21), p.12168-12173
Hauptverfasser:	Gao, Hanlin, Huang, Kuan-Chun, Yamasaki, Edith F., Chan, Kenneth K., Chohan, Lubna, Snapka, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antineoplastics Biological Sciences Cell cycle Cell lines Crosslinking DNA Enzymes Poisons quinoxaline phenoxypropionic acid Tumors Ultracentrifugation XK469
Online-Zugang:	Volltext
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