An Inverse Relationship between T Cell Receptor Affinity and Antigen Dose during CD4+ T Cell Responses in vivo and in vitro

Multimeric peptide/class II MHC staining reagents were synthesized and shown to bind with appropriate specificity to T cell hybridomas. A small, expanded population of T cells detected with one of these reagents in peptide-immunized C57BL/10 mice persisted for several months. This population expande...

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