Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

Ubiquitin-dependent degradation of regulatory proteins controls many cellular processes, including cell cycle progression morphogenesis, and signal transduction. Skp1p-cullin-F-box protein (SCF) complexes are ubiquitin ligases composed of a core complex including Skp1p, Cdc53p, one of multiple F-box...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-08, Vol.96 (16), p.9124-9129
Hauptverfasser:	Galan, J.M, Peter, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies auto-ubiquitination binding Biological Sciences Catalysis Cell cycle Cell Cycle - physiology Cell cycle proteins Cell Cycle Proteins - metabolism Cells Cellular biology cytochemistry Enzymes F box proteins Fungal Proteins - metabolism Genotype Half lives Immunoblotting Peptide Synthases - metabolism proteasomes protein degradation proteinases Proteins proteolysis Repressor Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins scf complexes SKP Cullin F-Box Protein Ligases Substrate Specificity Trans-Activators - metabolism ubiquitin ubiquitin ligase ubiquitin-conjugating enzyme Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases ubiquitination Ubiquitins Ubiquitins - metabolism Yeasts
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