Alloantigen-Induced Unresponsiveness in Cord Blood T Lymphocytes is Associated with Defective Activation of Ras

Human umbilical cord blood T lymphocytes (CBTL) respond to primary allostimulation but they do not proliferate upon rechallenge with alloantigen. Using PKH-26-labeled cells created a proliferative block that was observed only in CBTL that have divided during primary stimulation (PKH-26dim) but not i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-04, Vol.95 (8), p.4538-4543
Hauptverfasser:	Porcu, Pierluigi, Gaddy, Jay, Broxmeyer, Hal E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Antigens, CD - immunology Biological Sciences Blood CD28 Antigens - immunology Cell lines Cells, Cultured Cord blood Cultured cells Female Fetal Blood - immunology Flow Cytometry Fluorescent Dyes Humans Immunology Immunoprecipitation Infant, Newborn Ionomycin - pharmacology Isoantigens Isoantigens - immunology Lymphocyte Activation Organic Chemicals Pregnancy Proteins ras Proteins - metabolism Receptors Receptors, Antigen, T-Cell - physiology Signal Transduction - immunology T cell antigen receptors T lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology Tetradecanoylphorbol Acetate - pharmacology Tissue grafting
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