Upstream A-Tracts Increase Bacterial Promoter Activity through Interactions with the RNA Polymerase α Subunit

Upstream A-tracts stimulate transcription from a variety of bacterial promoters, and this has been widely attributed to direct effects of the intrinsic curvature of A-tract-containing DNA. In this work we report experiments that suggest a different mechanism for the effects of upstream A-tracts on t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-12, Vol.95 (25), p.14652-14657
Hauptverfasser:	Aiyar, Sarah E., Gourse, Richard L., Ross, Wilma
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biochemistry Biological Sciences Curvature DNA DNA, Bacterial - genetics DNA-Directed RNA Polymerases - genetics Escherichia coli Escherichia coli - genetics Gels Gene Expression Regulation Hybridity Molecular Sequence Data Nucleic acids Plasmids Promoter regions Promoter Regions, Genetic - genetics RNA
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