Inactivation of DNA Proofreading Obviates the Need for SOS Induction in Frameshift Mutagenesis

Translesion synthesis at replication-blocking lesions requires the induction of proteins that are controlled by the SOS system in Escherichia coli. Of the proteins identified so far, UmuD′, UmuC, and RecA*were shown to facilitate replication across UV-light-induced lesions, yielding both error-free...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-10, Vol.95 (22), p.13114-13119
Hauptverfasser:	Robert P. P. Fuchs, Napolitano, Rita L.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene - pharmacology Adducts Alleles Bacterial Proteins - metabolism Base Sequence Biological Sciences Cytosine Deoxyribonucleic acid DNA DNA Replication Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli - radiation effects Frameshift Mutation Genetic mutation Genetic SOS response Genetic vectors Genetics Lesions Models, Genetic Mutagenesis Plasmids Plasmids - drug effects Plasmids - genetics Plasmids - radiation effects Proofreading SOS Response (Genetics) - genetics Templates, Genetic Ultraviolet radiation Ultraviolet Rays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!