Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice

To test directly whether fibrin(ogen) is a key binding site for apolipoprotein(a) [apo(a)] in vessel walls, apo(a) transgenic mice and fibrinogen knockout mice were crossed to generate fibrin(ogen)-deficient apo(a) transgenic mice and control mice. In the vessel wall of apo(a) transgenic mice, fibri...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-10, Vol.95 (21), p.12591-12595
Hauptverfasser:	Lou, X.J. (Stanford University School of Medicine, Stanford, CA.), Boonmark, N.W, Horrigan, F.T, Degen, J.L, Lawn, R.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Afibrinogenemia Afibrinogenemia - metabolism ANIMAL TRANSGENIQUE ANIMALES TRANSGENICOS Animals AORTA Aorta - metabolism Apolipoproteins - genetics Apolipoproteins - metabolism Apoprotein(a) APOPROTEINAS APOPROTEINE APOPROTEINS ARTERE ARTERIAS ARTERIES ARTERIOSCLEROSE ARTERIOSCLEROSIS Arteriosclerosis - metabolism Atherosclerosis Biological Sciences Cardiovascular disease CHEMISTRY CHIMIE Cholesterols CONSOMMATION ALIMENTAIRE CONSUMO DE ALIMENTOS Coronary vessels CORPS GRAS DEPOSITION DIET DIETA FATS FATTY STREAK LESIONS FIBRINOGEN FIBRINOGENE FIBRINOGENO FOOD CONSUMPTION GENERO HUMANO GENRE HUMAIN GRASAS HIGH FAT DIET Humans IMMUNOHISTOCHEMISTRY IMMUNOLOGIE IMMUNOLOGY INMUNOLOGIA Lawns LESION LESIONES LESIONS LIPIDE LIPIDOS LIPIDS Lipoprotein(a) MANKIND MICE Mice, Inbred C57BL Mice, Transgenic Proteins QUIMICA RATON REGIME ALIMENTAIRE Rodents SOURIS TRANSGENIC ANIMALS
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