The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations

The Saccharomyces cerevisiae genome encodes four MutL homologs. Of these, MLH1 and PMS1 are known to act in the MSH2-dependent pathway that repairs DNA mismatches. We have investigated the role of NLH3 in mismatch repair. Mutations in MLH3 increased the rate of reversion of the hom3-10 allele by inc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-10, Vol.95 (21), p.12404-12409
Hauptverfasser:	Flores-Rozas, H. (University of California, La Jolla, CA.), Kolodner, R.D
Format:	Artikel
Sprache:	eng
Schlagworte:	ADN ALLELES Base Sequence Biological Sciences DNA DNA MISMATCH REPAIR DNA REPAIR DNA, Fungal FENOTIPOS Frameshift Mutation GENE GENES Genes, Fungal GENETIC CHANGE Genetic mutation GENETIC REVERSION GENETICA GENETICS GENETIQUE HOM3-10 ALLELE LYS2-BGL ALLELE METHYL METHANESULFONATE MMS MUTACION MUTAGENESIS MUTANT MUTANTES MUTANTS MUTATION MUTATION RATE MUTATOR PHENOTYPES Nucleotides Open reading frames PHENOTYPE PHENOTYPES Plasmids Polymerase chain reaction RADIACION ULTRAVIOLETA RAYONNEMENT ULTRAVIOLET SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - genetics STRUCTURAL GENES SUSCEPTIBILITY ULTRAVIOLET RADIATION Yeast Yeasts
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