Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene

Albright hereditary osteodystrophy (AHO), an autosomal dominant disorder characterized by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of GNAS1 , the gene encoding the heterotrimeric G protein α-subunit (G s α) that couples multiple receptors t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-07, Vol.95 (15), p.8715-8720
Hauptverfasser:	Yu, Shuhua, Yu, Dawen, Lee, Eric, Eckhaus, Michael, Lee, Randy, Corria, Zakia, Accili, Domenico, Westphal, Heiner, Weinstein, Lee S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences
Online-Zugang:	Volltext
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