DNA Looping by Ku and the DNA-Dependent Protein Kinase

The DNA-dependent protein kinase (DNA-PK) is required for DNA double-strand break (DSB) repair and immunoglobulin gene rearrangement and may play a role in the regulation of transcription. The DNA-PK holoenzyme is composed of three polypeptide subunits: the DNA binding Ku70/86 heterodimer and an ≈ 4...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-04, Vol.94 (9), p.4267-4272
Hauptverfasser:	Cary, Robert B., Peterson, Scott R., Wang, Jinting, Bear, David G., Bradbury, E. Morton, Chen, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear Atomic force microscopy Biochemistry Biological Sciences Chromatography Deoxyribonucleic acid DNA DNA - ultrastructure DNA Helicases DNA Repair DNA-Activated Protein Kinase DNA-Binding Proteins - metabolism DNA-Binding Proteins - ultrastructure Electron microscopy Gels HeLa Cells Heparin Humans Ku Autoantigen Microscopy, Atomic Force - methods Microscopy, Electron Molecules Nuclear Proteins - metabolism Nuclear Proteins - ultrastructure Nucleic Acid Conformation Protein Binding Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - ultrastructure Proteins Scientific imaging Statistical analysis
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