Daidzin Inhibits Mitochondrial Aldehyde Dehydrogenase and Suppresses Ethanol Intake of Syrian Golden Hamsters

Daidzin is the major active principle in extracts of radix puerariae, a traditional Chinese medication that suppresses the ethanol intake of Syrian golden hamsters. It is the first isoflavone recognized to have this effect. Daidzin is also a potent and selective inhibitor of human mitochondrial alde...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-03, Vol.94 (5), p.1675-1679
Hauptverfasser:	Keung, Wing Ming, Klyosov, Anatole A., Vallee, Bert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - metabolism Alcohol Deterrents - pharmacology Alcohol Drinking Aldehyde Dehydrogenase - antagonists & inhibitors Aldehydes Animals Biochemistry Biological Sciences Cricetinae Dehydrogenases Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Ethanol Golden hamsters Hamsters Humans Isoflavones Isoflavones - pharmacology Kinetics Liver Mesocricetus Metabolism Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Oxidation-Reduction Rats
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