Cell Cycle-Dependent Colocalization of BARD1 and BRCA1 Proteins in Discrete Nuclear Domains

Germ-line mutations of the BRCA1 gene predispose women to early-onset breast and ovarian cancer by compromising the gene's presumptive function as a tumor suppressor. Although the biochemical properties of BRCA1 polypeptides are not understood, their expression pattern and subcellular localizat...

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