Synergy between Adjacent Zinc Fingers in Sequence-Specific DNA Recognition

Zif268-like zinc fingers are generally regarded as independent DNA-binding modules that each specify three base pairs in adjacent, but discrete, subsites. However, crystallographic evidence suggests that a contact also can occur from the second helical position of one finger to the subsite of the pr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-05, Vol.94 (11), p.5617-5621
Hauptverfasser:	Isalan, Mark, Choo, Yen, Klug, Aaron
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Bacteriophages Binding Sites Biochemistry Biological Sciences Cloning, Molecular Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Enzyme-Linked Immunosorbent Assay Escherichia coli Fingers Genetic mutation Kinetics Libraries Models, Structural Molecular biology Molecular Sequence Data Mutagenesis, Site-Directed Nucleotides Polymerase Chain Reaction Protein Structure, Secondary Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sequence Deletion Transcription Factors - chemistry Transcription Factors - metabolism Zinc Zinc Fingers
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