A Mammalian Adaptor Protein with Conserved Src Homology 2 and Phosphotyrosine-Binding Domains is Related to Shc and is Specifically Expressed in the Brain

The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding (PTB) domain, and is itself phosphorylated on tyrosine in response to many extracellular signals. Pho...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (7), p.2729-2734
Hauptverfasser:	O'Bryan, John P., Songyang, Zhou, Cantley, Lewis, Der, Channing J., Pawson, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adaptor Proteins, Signal Transducing Amino Acid Sequence Amino acids Animals Antibodies Base Sequence Binding Sites Biochemistry Brain Brain - metabolism Cell Line Cloning, Molecular Complementary DNA Conserved Sequence DNA Primers Drosophila Drosophila - metabolism ErbB Receptors - metabolism Female Humans Mammals Mice Molecular Sequence Data Multigene Family Nerve Tissue Proteins - chemistry Neuropeptides Organ Specificity Phosphorylation Phosphotyrosine Polymerase Chain Reaction Protein Biosynthesis Proteins Proteins - chemistry Proteins - metabolism Receptors Receptors, Nerve Growth Factor - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism RNA Sequence Homology, Amino Acid Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 2 Src Homology 2 Domain-Containing, Transforming Protein 3 src Homology Domains
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