Pathogenesis of Influenza Virus-Induced Pneumonia: Involvement of Both Nitric Oxide and Oxygen Radicals

The role of nitric oxide (NO) in the pathogenesis of influenza virus-induced pneumonia in mice was investigated. Experimental influenza virus pneumonia was produced with influenza virus A/Kumamoto/ Y5/67(H2N2). Both the enzyme activity of NO synthase (NOS) and mRNA expression of the inducible NOS we...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-03, Vol.93 (6), p.2448-2453
Hauptverfasser:	Akaike, Takaaki, Noguchi, Yoichiro, Ijiri, Sumiko, Setoguchi, Keisuke, Suga, Moritaka, Zheng, Yong Mu, Dietzschold, Bernhard, Maeda, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Arginine - analogs & derivatives Arginine - pharmacology Biochemistry Electron paramagnetic resonance Electron Spin Resonance Spectroscopy Enzyme Induction Enzyme Inhibitors - pharmacology Free Radicals Infections Influenza Influenza A virus - pathogenicity influenza virus Interferon-gamma - physiology Lung - metabolism Lungs Macrophages Male Messenger RNA Mice Murine pneumonia virus Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis omega-N-Methylarginine Orthomyxoviridae Oxygen Pathology Pneumonia Pneumonia, Viral - physiopathology Pulmonary alveoli Reactive Oxygen Species - metabolism Rodents Superoxides - metabolism Viruses
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