The in vitro Ejection of Zinc from Human Immunodeficiency Virus (HIV) Type 1 Nucleocapsid Protein by Disulfide Benzamides with Cellular Anti-HIV Activity

Several disulfide benzamides have been shown to possess wide-spectrum antiretroviral activity in cell culture at low micromolar to submicromolar concentrations, inhibiting human immunodeficiency virus (HIV) type 1 (HIV-1) clinical and drug-resistant strains along with HIV-2 and simian immunodeficien...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-02, Vol.93 (3), p.969-973
Hauptverfasser:	Tummino, Peter J., Scholten, Jeffrey D., Harvey, Patricia J., Holler, Tod P., Maloney, Lisa, Gogliotti, Rocco, Domagala, John, Hupe, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Aminoquinolines Antiviral Agents - pharmacology Antivirals Benzamides Benzamides - pharmacology Capsid - drug effects Capsid - metabolism Cloning, Molecular Disulfides Disulfides - pharmacology Fluorescence Fluorescent Dyes Gels HIV HIV 1 HIV-1 - drug effects HIV-1 - metabolism human immunodeficiency virus 1 Humans Kinetics Molecular Sequence Data Recombinant Proteins - drug effects Recombinant Proteins - metabolism RNA Structure-Activity Relationship Tosyl Compounds Tryptophan Viral Core Proteins - drug effects Viral Core Proteins - metabolism Zinc Zinc - metabolism
Online-Zugang:	Volltext
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