1,25-Dihydroxyvitamin D3 Reversibly Blocks the Progression of Relapsing Encephalomyelitis, a Model of Multiple Sclerosis
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1996-07, Vol.93 (15), p.7861-7864 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Cantorna, Margherita T. Hayes, Colleen E. DeLuca, Hector F. |
| description | Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS. |
| doi_str_mv | 10.1073/pnas.93.15.7861 |
| format | Article |
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Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. 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Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.</description><subject>Animals</subject><subject>Calcitriol - analogs & derivatives</subject><subject>Calcitriol - therapeutic use</subject><subject>Central nervous system</subject><subject>Diet</subject><subject>Disease models</subject><subject>Disease Progression</subject><subject>Encephalitis</subject><subject>Encephalomyelitis, Autoimmune, Experimental - physiopathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - prevention & control</subject><subject>Encephalomyelitis, Autoimmune, Experimental - therapy</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Multiple Sclerosis</subject><subject>Mycobacterium tuberculosis</subject><subject>Myelin Basic Protein - immunology</subject><subject>Relapse</subject><subject>Rodents</subject><subject>Spinal Cord</subject><subject>T lymphocytes</subject><subject>Time Factors</subject><subject>Vitamin D</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - physiopathology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctv1DAQxiMEKkvhjIQEsjiUS7P12PEjEhdoy0NqBeJxtryOs-vFiYOdrHb_-ybaZUU5cBppvt83mpkvy54DngMW9KJrdZqXdA5sLiSHB9kMcAk5L0r8MJthTEQuC1I8zp6ktMYYl0zik-xECsYYF7NsC-eE5Vdutati2O42rteNa9EVRd_sxsbkFn6H3vtgfiXUryz6GsMy2pRcaFGoR8jrLrl2ia5bY7uV9qHZWe96l86RRrehsn7ibgffu85b9N14G0Ny6Wn2qNY-2WeHepr9_HD94_JTfvPl4-fLdze5KbiEXBtZE00IGFPUWmNecQMgdCVKbRZMggZBBNfAZDH2ZMU55ZJWVVlZTKygp9nb_dxuWDS2Mrbto_aqi67RcaeCduq-0rqVWoaNolLScrSfHewx_B5s6lXjkrHe69aGISkhCS9JMYGv_wHXYYjteJoiGCgBBmSELvaQGX-Qoq2PewBWU55qylOVVAFTU56j4-Xf6x_5Q4Cj_uqgT8Y_6r0Bb_4LqHrwvrfbfiRf7Ml16kM8ogUGIugdnAS-4Q</recordid><startdate>19960723</startdate><enddate>19960723</enddate><creator>Cantorna, Margherita T.</creator><creator>Hayes, Colleen E.</creator><creator>DeLuca, Hector F.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960723</creationdate><title>1,25-Dihydroxyvitamin D3 Reversibly Blocks the Progression of Relapsing Encephalomyelitis, a Model of Multiple Sclerosis</title><author>Cantorna, Margherita T. ; Hayes, Colleen E. ; DeLuca, Hector F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4681-ac8f2a221cc4faa06d6c117ad79acb581a17276a1584d798d663683dd9de02e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Calcitriol - analogs & derivatives</topic><topic>Calcitriol - therapeutic use</topic><topic>Central nervous system</topic><topic>Diet</topic><topic>Disease models</topic><topic>Disease Progression</topic><topic>Encephalitis</topic><topic>Encephalomyelitis, Autoimmune, Experimental - physiopathology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - prevention & control</topic><topic>Encephalomyelitis, Autoimmune, Experimental - therapy</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Immunity (Disease)</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Multiple Sclerosis</topic><topic>Mycobacterium tuberculosis</topic><topic>Myelin Basic Protein - immunology</topic><topic>Relapse</topic><topic>Rodents</topic><topic>Spinal Cord</topic><topic>T lymphocytes</topic><topic>Time Factors</topic><topic>Vitamin D</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cantorna, Margherita T.</creatorcontrib><creatorcontrib>Hayes, Colleen E.</creatorcontrib><creatorcontrib>DeLuca, Hector F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cantorna, Margherita T.</au><au>Hayes, Colleen E.</au><au>DeLuca, Hector F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1,25-Dihydroxyvitamin D3 Reversibly Blocks the Progression of Relapsing Encephalomyelitis, a Model of Multiple Sclerosis</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1996-07-23</date><risdate>1996</risdate><volume>93</volume><issue>15</issue><spage>7861</spage><epage>7864</epage><pages>7861-7864</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). 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| subjects | Animals Calcitriol - analogs & derivatives Calcitriol - therapeutic use Central nervous system Diet Disease models Disease Progression Encephalitis Encephalomyelitis, Autoimmune, Experimental - physiopathology Encephalomyelitis, Autoimmune, Experimental - prevention & control Encephalomyelitis, Autoimmune, Experimental - therapy Female Guinea Pigs Humans Immunity (Disease) Male Mice Mice, Inbred Strains Multiple Sclerosis Mycobacterium tuberculosis Myelin Basic Protein - immunology Relapse Rodents Spinal Cord T lymphocytes Time Factors Vitamin D Vitamin D deficiency Vitamin D Deficiency - physiopathology |
| title | 1,25-Dihydroxyvitamin D3 Reversibly Blocks the Progression of Relapsing Encephalomyelitis, a Model of Multiple Sclerosis |
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