A Nerve Growth Factor Peptide Retards Seizure Development and Inhibits Neuronal Sprouting in a Rat Model of Epilepsy
Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimi...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1995-10, Vol.92 (21), p.9495-9499 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 92 |
| creator | Rashid, Kashif Catharina E. E. M. Van der Zee Ross, Gregory M. Chapman, C. Andrew Stanisz, Jolanta Riopelle, Richard J. Racine, Ronald J. Fahnestock, Margaret |
| description | Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization. |
| doi_str_mv | 10.1073/pnas.92.21.9495 |
| format | Article |
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E. M. Van der Zee ; Ross, Gregory M. ; Chapman, C. Andrew ; Stanisz, Jolanta ; Riopelle, Richard J. ; Racine, Ronald J. ; Fahnestock, Margaret</creator><creatorcontrib>Rashid, Kashif ; Catharina E. E. M. Van der Zee ; Ross, Gregory M. ; Chapman, C. Andrew ; Stanisz, Jolanta ; Riopelle, Richard J. ; Racine, Ronald J. ; Fahnestock, Margaret</creatorcontrib><description>Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.92.21.9495</identifier><identifier>PMID: 7568161</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biological Assay ; Brain ; Brain-Derived Neurotrophic Factor ; Dentate gyrus ; Electric Stimulation ; Epilepsy ; Epilepsy - metabolism ; Epilepsy - prevention & control ; Epilepsy - veterinary ; Ganglia - cytology ; Ganglia - drug effects ; Ganglia, Spinal - cytology ; Ganglia, Spinal - drug effects ; Hippocampus - cytology ; Hippocampus - drug effects ; Histocytochemistry ; Kindling ; Kindling, Neurologic - drug effects ; Male ; Messenger RNA ; Nerve Fibers - drug effects ; Nerve Growth Factors - administration & dosage ; Nerve Growth Factors - genetics ; Nerve Growth Factors - pharmacology ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - pharmacology ; Neurites ; Neurology ; Neurons ; Neuroscience ; Neurotrophin 3 ; Peptide Fragments - administration & dosage ; Peptide Fragments - pharmacology ; Peptides ; Rats ; Receptors ; Receptors, Nerve Growth Factor - metabolism ; Ribonucleic acid ; RNA ; Rodents ; Seizures ; Seizures - prevention & control ; Sprouting ; Superior Cervical Ganglion - cytology ; Superior Cervical Ganglion - drug effects</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1995-10, Vol.92 (21), p.9495-9499</ispartof><rights>Copyright 1995 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Oct 10, 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-cd3a50a25bdf2f3d401b5c3d9a57932645480cdf1d2697517c82019a033095243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/92/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2368502$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2368502$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7568161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rashid, Kashif</creatorcontrib><creatorcontrib>Catharina E. E. M. Van der Zee</creatorcontrib><creatorcontrib>Ross, Gregory M.</creatorcontrib><creatorcontrib>Chapman, C. Andrew</creatorcontrib><creatorcontrib>Stanisz, Jolanta</creatorcontrib><creatorcontrib>Riopelle, Richard J.</creatorcontrib><creatorcontrib>Racine, Ronald J.</creatorcontrib><creatorcontrib>Fahnestock, Margaret</creatorcontrib><title>A Nerve Growth Factor Peptide Retards Seizure Development and Inhibits Neuronal Sprouting in a Rat Model of Epilepsy</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.</description><subject>Animals</subject><subject>Biological Assay</subject><subject>Brain</subject><subject>Brain-Derived Neurotrophic Factor</subject><subject>Dentate gyrus</subject><subject>Electric Stimulation</subject><subject>Epilepsy</subject><subject>Epilepsy - metabolism</subject><subject>Epilepsy - prevention & control</subject><subject>Epilepsy - veterinary</subject><subject>Ganglia - cytology</subject><subject>Ganglia - drug effects</subject><subject>Ganglia, Spinal - cytology</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Histocytochemistry</subject><subject>Kindling</subject><subject>Kindling, Neurologic - drug effects</subject><subject>Male</subject><subject>Messenger RNA</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Growth Factors - administration & dosage</subject><subject>Nerve Growth Factors - genetics</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - pharmacology</subject><subject>Neurites</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neuroscience</subject><subject>Neurotrophin 3</subject><subject>Peptide Fragments - administration & dosage</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptides</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors, Nerve Growth Factor - metabolism</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Rodents</subject><subject>Seizures</subject><subject>Seizures - prevention & control</subject><subject>Sprouting</subject><subject>Superior Cervical Ganglion - cytology</subject><subject>Superior Cervical Ganglion - drug effects</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktvEzEUhS0EKqGwZgPIYgGrSf0cjyU2VWlLpfJQC2vLGXsaR854ansC5dfjUUJEWcDKi_Odo3vvMQDPMZpjJOjR0Os0l2RO8FwyyR-AGUYSVzWT6CGYIURE1TDCHoMnKa0QQpI36AAcCF43uMYzkI_hJxs3Fp7H8D0v4Zluc4jwix2yMxZe2ayjSfDaup9jtPC93VgfhrXtM9S9gRf90i1cTiVkjKHXHl4PMYzZ9TfQ9VDDK53hx2Csh6GDp4Pzdkh3T8GjTvtkn-3eQ_Dt7PTryYfq8vP5xcnxZdXyps5Va6jmSBO-MB3pqGEIL3hLjdRcSEpqxlmDWtNhQ2opOBZtQxCWGlFa9iSMHoJ329xhXKytacvUUXs1RLfW8U4F7dR9pXdLdRM2iqGGNMX-ZmeP4Xa0Kau1S631Xvc2jEkJwRnimP0XxALhmja0gK__AldhjOVsSZXJKRVCTNDRFmpjSCnabj8wRmoqXU2lK0kUwWoqvThe_rnnnt-1XPRXO30y_lbvBbz9J6C60ftsf-RCvtiSq1T-yR4ltG44IvQXxoLJ0Q</recordid><startdate>19951010</startdate><enddate>19951010</enddate><creator>Rashid, Kashif</creator><creator>Catharina E. E. M. Van der Zee</creator><creator>Ross, Gregory M.</creator><creator>Chapman, C. 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Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>7568161</pmid><doi>10.1073/pnas.92.21.9495</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1995-10, Vol.92 (21), p.9495-9499 |
| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological Assay Brain Brain-Derived Neurotrophic Factor Dentate gyrus Electric Stimulation Epilepsy Epilepsy - metabolism Epilepsy - prevention & control Epilepsy - veterinary Ganglia - cytology Ganglia - drug effects Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Hippocampus - cytology Hippocampus - drug effects Histocytochemistry Kindling Kindling, Neurologic - drug effects Male Messenger RNA Nerve Fibers - drug effects Nerve Growth Factors - administration & dosage Nerve Growth Factors - genetics Nerve Growth Factors - pharmacology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - pharmacology Neurites Neurology Neurons Neuroscience Neurotrophin 3 Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Peptides Rats Receptors Receptors, Nerve Growth Factor - metabolism Ribonucleic acid RNA Rodents Seizures Seizures - prevention & control Sprouting Superior Cervical Ganglion - cytology Superior Cervical Ganglion - drug effects |
| title | A Nerve Growth Factor Peptide Retards Seizure Development and Inhibits Neuronal Sprouting in a Rat Model of Epilepsy |
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