Generation of a High-Titer Retroviral Vector Capable of Expressing High Levels of the Human β-Globin Gene

Retrovirus-mediated gene transfer into hematopoietic cells may provide a means of treating both inherited and acquired diseases involving hematopoietic cells. Implementation of this approach for disorders resulting from mutations affecting the β-globin gene (e.g., β-thalassemia and sickle cell anemi...

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