Regulation of the Polarization of T Cells Toward Antigen-Presenting Cells by Ras-Related GTPase CDC42

The mechanisms by which cells rapidly polarize in the direction of external signals are not understood. Helper T cells, when contacted by an antigen-presenting cell, polarize their cytoskeletons toward the antigen-presenting cell within minutes. Here we show that, in T cells, the mammalian Ras-relat...

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