Switch Recombination in Normal IgA1+B Lymphocytes

Most B lymphocytes in normal individuals express two classes of cell-surface immunoglobulins, IgM and IgD. The specificity of the two antigen receptors is identical since they are produced by transcription and differential splicing of the same variable region gene segment to the heavy-chain constant...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-02, Vol.91 (4), p.1323-1327
Hauptverfasser:	Irsch, Johanns, Irlenbusch, Sigrid, Radl, Jiri, Burrows, Peter D., Cooper, Max D., Radbruch, Andreas H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens, CD - analysis B lymphocytes B-Lymphocyte Subsets - immunology Biological and medical sciences Blood Blood Cells - immunology Cell Cycle Cell lines Cell Separation - methods Cellular biology Cellular immunity Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic loci Genotype Humans Immunity (Disease) Immunobiology Immunoglobulin A - genetics Immunoglobulin A - immunology Immunoglobulin Class Switching Immunoglobulin Constant Regions - genetics Immunoglobulin Heavy Chains - genetics Immunoglobulin Isotypes Immunophenotyping Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Myeloid cells Natural killer cells Plasma cells Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Recombination, Genetic Spleen cells
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