Pineal Control of Aging: Effect of Melatonin and Pineal Grafting on Aging Mice

Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-01, Vol.91 (2), p.787-791
Hauptverfasser:	Pierpaoli, Walter, Regelson, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging & longevity Aging - drug effects Aging - pathology Aging - physiology Animals Biological and medical sciences Biological Clocks Circadian Rhythm Development. Metamorphosis. Moult. Ageing Ethanol Female Fundamental and applied biological sciences. Psychology Hormonal regulation Hormones Immune response Male Melatonin - administration & dosage Melatonin - pharmacology Melatonin - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Physiology Pineal gland Pineal Gland - anatomy & histology Pineal Gland - physiology Pineal Gland - transplantation Potable water Rodents Thymus Gland - anatomy & histology Thymus Gland - physiology Thyroid Gland - anatomy & histology Thyroid Gland - physiology Tissue grafting Transplantation, Heterotopic Transplantation, Isogeneic Vertebrates: anatomy and physiology, studies on body, several organs or systems
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