Pineal Control of Aging: Effect of Melatonin and Pineal Grafting on Aging Mice
Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1994-01, Vol.91 (2), p.787-791 |
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| creator | Pierpaoli, Walter Regelson, William |
| description | Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months and C57BL/6 males beginning at 19 months. As melatonin is produced in circadian fashion from the pineal, we grafted pineals from young 3- to 4-month-old donors into the thymus of 20-month-old syngeneic C57BL/6 male recipients, and a 12% increase in survival was induced. Prolongation of survival was also seen on pineal transplant to the thymus in C57BL/6, BALB/cJ, and hybrid female mice at 16, 19, and 22 months. In all studies, the endogenous pineal of grafted mice was left in situ. Pineal grafted aged mice display a remarkable maintenance of thymic structure and cellularity. Preservation of T-cell-mediated function, despite age, as measured by response to oxazolone is seen. Other evidence suggests that melatonin and/or pineal-related factors could produce their effects through an influence on thyroid function. These data indicate that pineal influences have a place in the physiologic regulation of aging. |
| doi_str_mv | 10.1073/pnas.91.2.787 |
| format | Article |
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Similar results were seen in New Zealand Black females beginning at 5 months and C57BL/6 males beginning at 19 months. As melatonin is produced in circadian fashion from the pineal, we grafted pineals from young 3- to 4-month-old donors into the thymus of 20-month-old syngeneic C57BL/6 male recipients, and a 12% increase in survival was induced. Prolongation of survival was also seen on pineal transplant to the thymus in C57BL/6, BALB/cJ, and hybrid female mice at 16, 19, and 22 months. In all studies, the endogenous pineal of grafted mice was left in situ. Pineal grafted aged mice display a remarkable maintenance of thymic structure and cellularity. Preservation of T-cell-mediated function, despite age, as measured by response to oxazolone is seen. Other evidence suggests that melatonin and/or pineal-related factors could produce their effects through an influence on thyroid function. These data indicate that pineal influences have a place in the physiologic regulation of aging.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.91.2.787</identifier><identifier>PMID: 8290600</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Age ; Aging & longevity ; Aging - drug effects ; Aging - pathology ; Aging - physiology ; Animals ; Biological and medical sciences ; Biological Clocks ; Circadian Rhythm ; Development. Metamorphosis. Moult. Ageing ; Ethanol ; Female ; Fundamental and applied biological sciences. Psychology ; Hormonal regulation ; Hormones ; Immune response ; Male ; Melatonin - administration & dosage ; Melatonin - pharmacology ; Melatonin - physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Physiology ; Pineal gland ; Pineal Gland - anatomy & histology ; Pineal Gland - physiology ; Pineal Gland - transplantation ; Potable water ; Rodents ; Thymus Gland - anatomy & histology ; Thymus Gland - physiology ; Thyroid Gland - anatomy & histology ; Thyroid Gland - physiology ; Tissue grafting ; Transplantation, Heterotopic ; Transplantation, Isogeneic ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1994-01, Vol.91 (2), p.787-791</ispartof><rights>Copyright 1994 The National Academy of Sciences of the United States of America</rights><rights>1994 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Jan 18, 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-caac2a39860eb4cabf2ae5b6007894a58e73a970b8c8dfc108c86a459c4a20d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/91/2.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2363969$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2363969$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3928837$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8290600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pierpaoli, Walter</creatorcontrib><creatorcontrib>Regelson, William</creatorcontrib><title>Pineal Control of Aging: Effect of Melatonin and Pineal Grafting on Aging Mice</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months and C57BL/6 males beginning at 19 months. As melatonin is produced in circadian fashion from the pineal, we grafted pineals from young 3- to 4-month-old donors into the thymus of 20-month-old syngeneic C57BL/6 male recipients, and a 12% increase in survival was induced. Prolongation of survival was also seen on pineal transplant to the thymus in C57BL/6, BALB/cJ, and hybrid female mice at 16, 19, and 22 months. In all studies, the endogenous pineal of grafted mice was left in situ. Pineal grafted aged mice display a remarkable maintenance of thymic structure and cellularity. Preservation of T-cell-mediated function, despite age, as measured by response to oxazolone is seen. Other evidence suggests that melatonin and/or pineal-related factors could produce their effects through an influence on thyroid function. These data indicate that pineal influences have a place in the physiologic regulation of aging.</description><subject>Age</subject><subject>Aging & longevity</subject><subject>Aging - drug effects</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Clocks</subject><subject>Circadian Rhythm</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Ethanol</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormonal regulation</subject><subject>Hormones</subject><subject>Immune response</subject><subject>Male</subject><subject>Melatonin - administration & dosage</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Physiology</subject><subject>Pineal gland</subject><subject>Pineal Gland - anatomy & histology</subject><subject>Pineal Gland - physiology</subject><subject>Pineal Gland - transplantation</subject><subject>Potable water</subject><subject>Rodents</subject><subject>Thymus Gland - anatomy & histology</subject><subject>Thymus Gland - physiology</subject><subject>Thyroid Gland - anatomy & histology</subject><subject>Thyroid Gland - physiology</subject><subject>Tissue grafting</subject><subject>Transplantation, Heterotopic</subject><subject>Transplantation, Isogeneic</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEKkvhyA2kCBVuWcZ24tiIS7UqBakFDnC2Jl57ycprb-0ElX-Pow1L4QCnkfy-9zz2K4qnBJYEWvZ67zEtJVnSZSvae8WCgCQVryXcLxYAtK1ETeuHxaOUtgAgGwEnxYmgEjjAovj4ufcGXbkKfojBlcGW55veb96UF9YaPUwH18bhEHzvS_TrcjZcRrRDBsvgD47yutfmcfHAokvmyTxPi6_vLr6s3ldXny4_rM6vKs2hGSqNqCkyKTiYrtbYWYqm6fJGrZA1NsK0DGULndBibTWBPDnWjdQ1Ulhzdlq8PeTux25n1trk7dGpfex3GH-ogL36U_H9N7UJ31XNgNXZ_mq2x3AzmjSoXZ-0cQ69CWNSLWeM01r8FyQ8o207Jb74C9yGMfr8B4oCYYwIMUHVAdIxpBSNPS5MQE1lqqlMJYmiKpeZ-ed3X3mk5_ayfjbrmDQ6G9HrPh0xJqkQbIp5NmNT-i_1zi0v_yErOzo3mNvhd8w2DSEeQco4k1yyn10jx2A</recordid><startdate>19940118</startdate><enddate>19940118</enddate><creator>Pierpaoli, Walter</creator><creator>Regelson, William</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940118</creationdate><title>Pineal Control of Aging: Effect of Melatonin and Pineal Grafting on Aging Mice</title><author>Pierpaoli, Walter ; Regelson, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-caac2a39860eb4cabf2ae5b6007894a58e73a970b8c8dfc108c86a459c4a20d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Age</topic><topic>Aging & longevity</topic><topic>Aging - drug effects</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Clocks</topic><topic>Circadian Rhythm</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Ethanol</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormonal regulation</topic><topic>Hormones</topic><topic>Immune response</topic><topic>Male</topic><topic>Melatonin - administration & dosage</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Physiology</topic><topic>Pineal gland</topic><topic>Pineal Gland - anatomy & histology</topic><topic>Pineal Gland - physiology</topic><topic>Pineal Gland - transplantation</topic><topic>Potable water</topic><topic>Rodents</topic><topic>Thymus Gland - anatomy & histology</topic><topic>Thymus Gland - physiology</topic><topic>Thyroid Gland - anatomy & histology</topic><topic>Thyroid Gland - physiology</topic><topic>Tissue grafting</topic><topic>Transplantation, Heterotopic</topic><topic>Transplantation, Isogeneic</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pierpaoli, Walter</creatorcontrib><creatorcontrib>Regelson, William</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pierpaoli, Walter</au><au>Regelson, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pineal Control of Aging: Effect of Melatonin and Pineal Grafting on Aging Mice</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1994-01-18</date><risdate>1994</risdate><volume>91</volume><issue>2</issue><spage>787</spage><epage>791</epage><pages>787-791</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months and C57BL/6 males beginning at 19 months. As melatonin is produced in circadian fashion from the pineal, we grafted pineals from young 3- to 4-month-old donors into the thymus of 20-month-old syngeneic C57BL/6 male recipients, and a 12% increase in survival was induced. Prolongation of survival was also seen on pineal transplant to the thymus in C57BL/6, BALB/cJ, and hybrid female mice at 16, 19, and 22 months. In all studies, the endogenous pineal of grafted mice was left in situ. Pineal grafted aged mice display a remarkable maintenance of thymic structure and cellularity. Preservation of T-cell-mediated function, despite age, as measured by response to oxazolone is seen. Other evidence suggests that melatonin and/or pineal-related factors could produce their effects through an influence on thyroid function. These data indicate that pineal influences have a place in the physiologic regulation of aging.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8290600</pmid><doi>10.1073/pnas.91.2.787</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1994-01, Vol.91 (2), p.787-791 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Age Aging & longevity Aging - drug effects Aging - pathology Aging - physiology Animals Biological and medical sciences Biological Clocks Circadian Rhythm Development. Metamorphosis. Moult. Ageing Ethanol Female Fundamental and applied biological sciences. Psychology Hormonal regulation Hormones Immune response Male Melatonin - administration & dosage Melatonin - pharmacology Melatonin - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Physiology Pineal gland Pineal Gland - anatomy & histology Pineal Gland - physiology Pineal Gland - transplantation Potable water Rodents Thymus Gland - anatomy & histology Thymus Gland - physiology Thyroid Gland - anatomy & histology Thyroid Gland - physiology Tissue grafting Transplantation, Heterotopic Transplantation, Isogeneic Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Pineal Control of Aging: Effect of Melatonin and Pineal Grafting on Aging Mice |
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