Direct Observation of Substance P-Induced Internalization of Neurokinin 1 (NK1) Receptors at Sites of Inflammation

Substance P (SP) can cause plasma leakage at sites of inflammation by binding to neurokinin type 1 (NK1) receptors on the surface of endothelial cells. Internalization after ligand binding could reduce the number of NK1receptors on the cell surface and thus participate in the desensitization and res...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-09, Vol.91 (19), p.8964-8968
Hauptverfasser:	Bowden, Jeffrey J., Garland, Adella M., Baluk, Peter, Lefevre, Peter, Grady, Eileen F., Vigna, Steven R., Bunnett, Nigel W., McDonald, Donald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biochemistry Blood plasma Calcium - physiology Capillary Permeability Cell Line Cell surface receptors Cellular biology Down-Regulation Endocytosis Endosomes Endosomes - metabolism Endothelial cells Endothelium, Vascular - metabolism In Vitro Techniques Inflammation - metabolism Internalization Inurement Male Neurons Rats Rats, Inbred F344 Receptors Receptors, Neurokinin-1 - metabolism Rodents Signal Transduction Substance P - metabolism Substance P - pharmacology Trachea Trachea - cytology Trachea - metabolism Venules
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