Neural Expression and Chromosomal Mapping of Neu Differentiation Factor to 8p12-p21

Neu differentiation factor (NDF/heregulin) is a 44-kDa glycoprotein that interacts with the Neu/ErbB-2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. In vitro NDF promotes differentiation of certain mammary tumor cell lines to milk-producing cells. As a first step tow...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-03, Vol.90 (5), p.1867-1871
Hauptverfasser:	Orr-Urtreger, Avi, Trakhtenbrot, Luba, Ben-Levy, Rachel, Wen, Duanzhi, Rechavi, Gideon, Lonai, Peter, Yarden, Yosef
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Cell lines Cells Cellular biology chromosome 8 Chromosome Mapping Chromosomes Chromosomes, Human, Pair 8 Cloning, Molecular DNA Embryos expression Fundamental and applied biological sciences. Psychology Gene Expression Genes Glycoproteins - genetics Glycoproteins - metabolism Human growth Humans In Situ Hybridization Ligands man mapping Mice Mice, Inbred C57BL Molecular Sequence Data Nervous system Neu differentiation factor Neuregulins Oligodeoxyribonucleotides - chemistry Oncogene Proteins, Viral - genetics Protein hormones. Growth factors. Cytokines Proteins Receptor, ErbB-2 Receptors RNA, Messenger - genetics tissues Transcription, Genetic Tumor cell line
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