Neural Expression and Chromosomal Mapping of Neu Differentiation Factor to 8p12-p21
Neu differentiation factor (NDF/heregulin) is a 44-kDa glycoprotein that interacts with the Neu/ErbB-2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. In vitro NDF promotes differentiation of certain mammary tumor cell lines to milk-producing cells. As a first step tow...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-03, Vol.90 (5), p.1867-1871 |
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| container_issue | 5 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 90 |
| creator | Orr-Urtreger, Avi Trakhtenbrot, Luba Ben-Levy, Rachel Wen, Duanzhi Rechavi, Gideon Lonai, Peter Yarden, Yosef |
| description | Neu differentiation factor (NDF/heregulin) is a 44-kDa glycoprotein that interacts with the Neu/ErbB-2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. In vitro NDF promotes differentiation of certain mammary tumor cell lines to milk-producing cells. As a first step toward understanding the physiological role of NDF, we performed in situ hybridization analyses to determine mRNA distribution in the mouse embryo and to map the gene to human karyotypes. In 14.5-day-postcoitum mouse embryos, NDF expression is confined predominantly to the central and peripheral nervous system, including the neuroepithelium that lines the lateral ventricles of the brain, the ventral horn of the spinal cord, and the intestinal as well as dorsal root ganglia. Other tissues that contain NDF transcripts are the adrenal gland, liver, and distinct cell layers of the dermis and germinal ridge. In situ hybridization of a3H-labeled probe to human metaphase spreads localized the NDF gene to the short arm of chromosome 8 at bands p12-p21. |
| doi_str_mv | 10.1073/pnas.90.5.1867 |
| format | Article |
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In vitro NDF promotes differentiation of certain mammary tumor cell lines to milk-producing cells. As a first step toward understanding the physiological role of NDF, we performed in situ hybridization analyses to determine mRNA distribution in the mouse embryo and to map the gene to human karyotypes. In 14.5-day-postcoitum mouse embryos, NDF expression is confined predominantly to the central and peripheral nervous system, including the neuroepithelium that lines the lateral ventricles of the brain, the ventral horn of the spinal cord, and the intestinal as well as dorsal root ganglia. Other tissues that contain NDF transcripts are the adrenal gland, liver, and distinct cell layers of the dermis and germinal ridge. In situ hybridization of a3H-labeled probe to human metaphase spreads localized the NDF gene to the short arm of chromosome 8 at bands p12-p21.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.5.1867</identifier><identifier>PMID: 8095334</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Base Sequence ; Biological and medical sciences ; Cell lines ; Cells ; Cellular biology ; chromosome 8 ; Chromosome Mapping ; Chromosomes ; Chromosomes, Human, Pair 8 ; Cloning, Molecular ; DNA ; Embryos ; expression ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Genes ; Glycoproteins - genetics ; Glycoproteins - metabolism ; Human growth ; Humans ; In Situ Hybridization ; Ligands ; man ; mapping ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Nervous system ; Neu differentiation factor ; Neuregulins ; Oligodeoxyribonucleotides - chemistry ; Oncogene Proteins, Viral - genetics ; Protein hormones. Growth factors. Cytokines ; Proteins ; Receptor, ErbB-2 ; Receptors ; RNA, Messenger - genetics ; tissues ; Transcription, Genetic ; Tumor cell line</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (5), p.1867-1871</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1993 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Mar 1, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-50d26d6449dde37c2a330b66ab6a0b82edb2fa8d9a1b73f7f68a9d1cd9d818343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/5.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2361419$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2361419$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4716110$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8095334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orr-Urtreger, Avi</creatorcontrib><creatorcontrib>Trakhtenbrot, Luba</creatorcontrib><creatorcontrib>Ben-Levy, Rachel</creatorcontrib><creatorcontrib>Wen, Duanzhi</creatorcontrib><creatorcontrib>Rechavi, Gideon</creatorcontrib><creatorcontrib>Lonai, Peter</creatorcontrib><creatorcontrib>Yarden, Yosef</creatorcontrib><title>Neural Expression and Chromosomal Mapping of Neu Differentiation Factor to 8p12-p21</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Neu differentiation factor (NDF/heregulin) is a 44-kDa glycoprotein that interacts with the Neu/ErbB-2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. In vitro NDF promotes differentiation of certain mammary tumor cell lines to milk-producing cells. As a first step toward understanding the physiological role of NDF, we performed in situ hybridization analyses to determine mRNA distribution in the mouse embryo and to map the gene to human karyotypes. In 14.5-day-postcoitum mouse embryos, NDF expression is confined predominantly to the central and peripheral nervous system, including the neuroepithelium that lines the lateral ventricles of the brain, the ventral horn of the spinal cord, and the intestinal as well as dorsal root ganglia. Other tissues that contain NDF transcripts are the adrenal gland, liver, and distinct cell layers of the dermis and germinal ridge. In situ hybridization of a3H-labeled probe to human metaphase spreads localized the NDF gene to the short arm of chromosome 8 at bands p12-p21.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell lines</subject><subject>Cells</subject><subject>Cellular biology</subject><subject>chromosome 8</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Cloning, Molecular</subject><subject>DNA</subject><subject>Embryos</subject><subject>expression</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - metabolism</subject><subject>Human growth</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Ligands</subject><subject>man</subject><subject>mapping</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Nervous system</subject><subject>Neu differentiation factor</subject><subject>Neuregulins</subject><subject>Oligodeoxyribonucleotides - chemistry</subject><subject>Oncogene Proteins, Viral - genetics</subject><subject>Protein hormones. Growth factors. Cytokines</subject><subject>Proteins</subject><subject>Receptor, ErbB-2</subject><subject>Receptors</subject><subject>RNA, Messenger - genetics</subject><subject>tissues</subject><subject>Transcription, Genetic</subject><subject>Tumor cell line</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EKkNhywqkCKHuEvyKHxIbNLSAVGABrK2b2G4zSuJgJ6j8exzNMBpYwMqWzneO7_VB6CnBFcGSvZpGSJXGVV0RJeQ9tCFYk1Jwje-jDcZUlopT_hA9SmmHMda1wmfoTOULY3yDvnxyS4S-uLybokupC2MBoy22tzEMIYUhSx9hmrrxpgi-yHDxtvPeRTfOHcwrfgXtHGIxh0JNhJYTJY_RAw99ck8O5zn6dnX5dfu-vP787sP2zXXZ1pzPZY0tFVZwrq11TLYUGMONENAIwI2izjbUg7IaSCOZl14o0Ja0VltFFOPsHL3e505LMzjb5pnyKmaK3QDxpwnQmT-Vsbs1N-GH4bVWJNsvDvYYvi8uzWboUuv6HkYXlmRkLRiWdf1fkAhOBdM6gy_-AndhiWP-A0MxoVxySjNU7aE2hpSi88eBCTZrpWat1GhsarNWmg3PT9c84ocOs_7yoENqofcRxrZLR4xLIgjBJzFr_G_19JmLf-nGL30_u7s5g8_24C7l4o8kZYJwotkv1a3Kdg</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Orr-Urtreger, Avi</creator><creator>Trakhtenbrot, Luba</creator><creator>Ben-Levy, Rachel</creator><creator>Wen, Duanzhi</creator><creator>Rechavi, Gideon</creator><creator>Lonai, Peter</creator><creator>Yarden, Yosef</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930301</creationdate><title>Neural Expression and Chromosomal Mapping of Neu Differentiation Factor to 8p12-p21</title><author>Orr-Urtreger, Avi ; Trakhtenbrot, Luba ; Ben-Levy, Rachel ; Wen, Duanzhi ; Rechavi, Gideon ; Lonai, Peter ; Yarden, Yosef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-50d26d6449dde37c2a330b66ab6a0b82edb2fa8d9a1b73f7f68a9d1cd9d818343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell lines</topic><topic>Cells</topic><topic>Cellular biology</topic><topic>chromosome 8</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 8</topic><topic>Cloning, Molecular</topic><topic>DNA</topic><topic>Embryos</topic><topic>expression</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - metabolism</topic><topic>Human growth</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Ligands</topic><topic>man</topic><topic>mapping</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Nervous system</topic><topic>Neu differentiation factor</topic><topic>Neuregulins</topic><topic>Oligodeoxyribonucleotides - chemistry</topic><topic>Oncogene Proteins, Viral - genetics</topic><topic>Protein hormones. Growth factors. 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In vitro NDF promotes differentiation of certain mammary tumor cell lines to milk-producing cells. As a first step toward understanding the physiological role of NDF, we performed in situ hybridization analyses to determine mRNA distribution in the mouse embryo and to map the gene to human karyotypes. In 14.5-day-postcoitum mouse embryos, NDF expression is confined predominantly to the central and peripheral nervous system, including the neuroepithelium that lines the lateral ventricles of the brain, the ventral horn of the spinal cord, and the intestinal as well as dorsal root ganglia. Other tissues that contain NDF transcripts are the adrenal gland, liver, and distinct cell layers of the dermis and germinal ridge. In situ hybridization of a3H-labeled probe to human metaphase spreads localized the NDF gene to the short arm of chromosome 8 at bands p12-p21.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8095334</pmid><doi>10.1073/pnas.90.5.1867</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (5), p.1867-1871 |
| issn | 0027-8424 1091-6490 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Cell lines Cells Cellular biology chromosome 8 Chromosome Mapping Chromosomes Chromosomes, Human, Pair 8 Cloning, Molecular DNA Embryos expression Fundamental and applied biological sciences. Psychology Gene Expression Genes Glycoproteins - genetics Glycoproteins - metabolism Human growth Humans In Situ Hybridization Ligands man mapping Mice Mice, Inbred C57BL Molecular Sequence Data Nervous system Neu differentiation factor Neuregulins Oligodeoxyribonucleotides - chemistry Oncogene Proteins, Viral - genetics Protein hormones. Growth factors. Cytokines Proteins Receptor, ErbB-2 Receptors RNA, Messenger - genetics tissues Transcription, Genetic Tumor cell line |
| title | Neural Expression and Chromosomal Mapping of Neu Differentiation Factor to 8p12-p21 |
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