Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation

The lymphoid-specific tyrosine kinase p56lck (Lck) is critical for the development and activation of T lymphocytes, and Lck kinase activity has been implicated in both T-cell antigen receptor/CD3- and CD4-mediated signaling. CD4-dependent T-cell activation has been demonstrated to be dependent upon...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-12, Vol.90 (24), p.11885-11889
Hauptverfasser:	COLLINS, T. L, BURAKOFF, S. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological and medical sciences CD4 Antigens - metabolism DNA Primers Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunoblotting Interleukin-2 - biosynthesis Kinetics Lymphocyte Activation Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Mutagenesis, Site-Directed Myelin Basic Protein - metabolism Phosphorylation Polymerase Chain Reaction Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Signal Transduction - physiology T-Lymphocytes - enzymology T-Lymphocytes - immunology Transfection
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