The mdm-2 Gene is Induced in Response to UV Light in a p53-Dependent Manner

Irradiation of mammalian cells with UV light results in a dose-dependent accumulation of the p53 tumor-suppressor gene product that is evident within 2 hr. UV treatment causes a dramatic increase in p53-specific transcriptional transactivation activity and an increase in expression of the p53-respon...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-12, Vol.90 (24), p.11623-11627
Hauptverfasser:	Perry, Mary Ellen, Piette, Jacques, Zawadzki, Jerome A., Harvey, Diane, Levine, Arnold J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 550400 - Genetics 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture Animals BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS CELL CYCLE Cell lines Cells Cells, Cultured Cellular biology Chloramphenicol O-Acetyltransferase - biosynthesis Colony-Forming Units Assay DNA DNA damage DNA Replication - radiation effects Dose-Response Relationship, Radiation ELECTROMAGNETIC RADIATION Fundamental and applied biological sciences. Psychology Gene Expression - radiation effects GENES Genes, p53 - radiation effects GENETIC EFFECTS GENETIC RADIATION EFFECTS Interphase Introns Irradiation Kinetics Medical research Mice Mice, Inbred BALB C Molecular and cellular biology Molecular genetics Mutagenesis. Repair Neoplasm Proteins - biosynthesis Nuclear Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS Time Factors Transactivation Transcription, Genetic Transfection Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - metabolism Tumors ULTRAVIOLET RADIATION Ultraviolet Rays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!