Electroporation of Mammalian Skin: A Mechanism to Enhance Transdermal Drug Delivery

Mammalian skin owes its remarkable barrier function to its outermost and dead layer, the stratum corneum. Transdermal transport through this region occurs predominantly through intercellular lipids, organized largely in bilayers. Electroporation is the creation of aqueous pores in lipid bilayers by...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-11, Vol.90 (22), p.10504-10508
Hauptverfasser:	Prausnitz, Mark R., Bose, Vanu G., Langer, Robert, Weaver, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Biological and medical sciences Cadaver Cell Membrane Permeability Drug therapy Electric fields Electric potential Electric pulses Electrodes Electroporation Electroporation - methods Epidermis Epidermis - physiology Fluoresceins - administration & dosage General pharmacology Humans In Vitro Techniques Medical research Medical sciences Membrane Potentials Molecules Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Skin Skin Physiological Phenomena Transdermal application
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