Relationship Between NMR Transverse Relaxation, Trabecular Bone Architecture, and Strength
Structure, biomechanical competence, and incremental NMR line broadening (R'2) of water in the intertrabecular spaces of cancellous bone were examined on 22 cylindrical specimens from the lumbar vertebral bodies of 16 human subjects 24-86 years old (mean, 60 years old). A strong association (r...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-11, Vol.90 (21), p.10250-10254 |
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| creator | Chung, H. Wehrli, F. W. Williams, J. L. Kugelmass, S. D. |
| description | Structure, biomechanical competence, and incremental NMR line broadening (R'2) of water in the intertrabecular spaces of cancellous bone were examined on 22 cylindrical specimens from the lumbar vertebral bodies of 16 human subjects 24-86 years old (mean, 60 years old). A strong association (r = 0.91; P < 0.0001) was found between Young's modulus of elasticity and R'2
for a wide range of values corresponding to cancellous bone of very different morphologic composition. NMR line broadening is caused by the inhomogeneity of the magnetic field induced as a consequence of the coexistence of two adjacent phases of different diamagnetic susceptibility-i.e., mineralized bone and water in the marrow spaces. Structural analyses performed by means of NMR microscopy and digital image processing indicated that the variation in R'2
is closely related to the trabecular microstructure. Mean trabecular plate density measured along the direction of the magnetic field was found to play a major role in predicting R'2
(r = 0.74; P < 0.0001). This behavior was confirmed when the plate density was varied in individual specimens, which was achieved by rotating the specimen, making use of the bone's structural anisotropy. It is concluded that the NMR transverse relaxation rate in human cancellous bone of the spine is significantly determined by trabecular structural parameters relevant to biomechanical strength. The results further underscore the important role played by the transverse trabeculae in contributing to cancellous bone strength. The work has implications on possible in vivo use of quantitative magnetic resonance for the assessment of fracture risk in osteoporotic patients. |
| doi_str_mv | 10.1073/pnas.90.21.10250 |
| format | Article |
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for a wide range of values corresponding to cancellous bone of very different morphologic composition. NMR line broadening is caused by the inhomogeneity of the magnetic field induced as a consequence of the coexistence of two adjacent phases of different diamagnetic susceptibility-i.e., mineralized bone and water in the marrow spaces. Structural analyses performed by means of NMR microscopy and digital image processing indicated that the variation in R'2
is closely related to the trabecular microstructure. Mean trabecular plate density measured along the direction of the magnetic field was found to play a major role in predicting R'2
(r = 0.74; P < 0.0001). This behavior was confirmed when the plate density was varied in individual specimens, which was achieved by rotating the specimen, making use of the bone's structural anisotropy. It is concluded that the NMR transverse relaxation rate in human cancellous bone of the spine is significantly determined by trabecular structural parameters relevant to biomechanical strength. The results further underscore the important role played by the transverse trabeculae in contributing to cancellous bone strength. The work has implications on possible in vivo use of quantitative magnetic resonance for the assessment of fracture risk in osteoporotic patients.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.21.10250</identifier><identifier>PMID: 8234285</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Anatomy & physiology ; Biological and medical sciences ; Bone and Bones - anatomy & histology ; Bone and Bones - physiology ; Bone density ; Bone marrow ; Bone Marrow - anatomy & histology ; Bone strength ; Bones ; Density ; Elasticity ; Humans ; Inhomogeneity ; Investigative techniques, diagnostic techniques (general aspects) ; Lumbar Vertebrae - anatomy & histology ; Lumbar Vertebrae - physiology ; Magnetic fields ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Middle Aged ; Models, Biological ; NMR ; Nuclear magnetic resonance ; Osteoarticular system. Muscles ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pixels ; Skeletal system ; Space life sciences ; Specimens ; Tensile Strength ; Youngs modulus</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-11, Vol.90 (21), p.10250-10254</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1994 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Nov 1, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-3042f0fa253980a7975af2bb46d2cc094d02eb24c1c8a7c51e95448d28ac72353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2363441$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2363441$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,309,310,314,723,776,780,785,786,799,881,23910,23911,25119,27903,27904,53770,53772,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3856971$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8234285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, H.</creatorcontrib><creatorcontrib>Wehrli, F. W.</creatorcontrib><creatorcontrib>Williams, J. L.</creatorcontrib><creatorcontrib>Kugelmass, S. D.</creatorcontrib><title>Relationship Between NMR Transverse Relaxation, Trabecular Bone Architecture, and Strength</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Structure, biomechanical competence, and incremental NMR line broadening (R'2) of water in the intertrabecular spaces of cancellous bone were examined on 22 cylindrical specimens from the lumbar vertebral bodies of 16 human subjects 24-86 years old (mean, 60 years old). A strong association (r = 0.91; P < 0.0001) was found between Young's modulus of elasticity and R'2
for a wide range of values corresponding to cancellous bone of very different morphologic composition. NMR line broadening is caused by the inhomogeneity of the magnetic field induced as a consequence of the coexistence of two adjacent phases of different diamagnetic susceptibility-i.e., mineralized bone and water in the marrow spaces. Structural analyses performed by means of NMR microscopy and digital image processing indicated that the variation in R'2
is closely related to the trabecular microstructure. Mean trabecular plate density measured along the direction of the magnetic field was found to play a major role in predicting R'2
(r = 0.74; P < 0.0001). This behavior was confirmed when the plate density was varied in individual specimens, which was achieved by rotating the specimen, making use of the bone's structural anisotropy. It is concluded that the NMR transverse relaxation rate in human cancellous bone of the spine is significantly determined by trabecular structural parameters relevant to biomechanical strength. The results further underscore the important role played by the transverse trabeculae in contributing to cancellous bone strength. The work has implications on possible in vivo use of quantitative magnetic resonance for the assessment of fracture risk in osteoporotic patients.</description><subject>Anatomy & physiology</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - anatomy & histology</subject><subject>Bone and Bones - physiology</subject><subject>Bone density</subject><subject>Bone marrow</subject><subject>Bone Marrow - anatomy & histology</subject><subject>Bone strength</subject><subject>Bones</subject><subject>Density</subject><subject>Elasticity</subject><subject>Humans</subject><subject>Inhomogeneity</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lumbar Vertebrae - anatomy & histology</subject><subject>Lumbar Vertebrae - physiology</subject><subject>Magnetic fields</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Osteoarticular system. Muscles</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pixels</subject><subject>Skeletal system</subject><subject>Space life sciences</subject><subject>Specimens</subject><subject>Tensile Strength</subject><subject>Youngs modulus</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxSMEKkvhzgFEhCrEobuMv2Jb4tJWfEkFpFIuXCzHmXSzyjpb2yntf0_SDavCAU7W-P3ejMcvy54SWBCQ7M3G27jQsKBkqKmAe9mMgCbzgmu4n80AqJwrTvnD7FGMKwDQQsFetqco41SJWfbjDFubms7HZbPJjzH9RPT5l89n-XmwPl5hiJiPzPUtdThel-j61ob8uPOYHwW3bBK61Ac8zK2v8m8poL9Iy8fZg9q2EZ9M5372_f2785OP89OvHz6dHJ3OnRA8zRlwWkNtqWBagZVaClvTsuRFRZ0DzSugWFLuiFNWOkFQC85VRZV1kjLB9rO3276bvlxj5dCnYFuzCc3ahhvT2cb8qfhmaS66K8OlFHSwv5rsobvsMSazbqLDtrUeuz4aWUBBOCX_BUlRKK1VMYAv_wJXXR_88AeGAqGiUEoOEGwhF7oYA9a7BxMwY7ZmzNZoMJSY22wHy_O7i-4MU5iDfjDpNjrb1kOArok7jClRaDnu8XrCxgG_1TuDTN23bcLrNKAv_o0OxLMtsYqpCzuEsoJxTtgvKcfOeg</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Chung, H.</creator><creator>Wehrli, F. W.</creator><creator>Williams, J. L.</creator><creator>Kugelmass, S. D.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19931101</creationdate><title>Relationship Between NMR Transverse Relaxation, Trabecular Bone Architecture, and Strength</title><author>Chung, H. ; Wehrli, F. W. ; Williams, J. 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W.</au><au>Williams, J. L.</au><au>Kugelmass, S. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between NMR Transverse Relaxation, Trabecular Bone Architecture, and Strength</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>90</volume><issue>21</issue><spage>10250</spage><epage>10254</epage><pages>10250-10254</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Structure, biomechanical competence, and incremental NMR line broadening (R'2) of water in the intertrabecular spaces of cancellous bone were examined on 22 cylindrical specimens from the lumbar vertebral bodies of 16 human subjects 24-86 years old (mean, 60 years old). A strong association (r = 0.91; P < 0.0001) was found between Young's modulus of elasticity and R'2
for a wide range of values corresponding to cancellous bone of very different morphologic composition. NMR line broadening is caused by the inhomogeneity of the magnetic field induced as a consequence of the coexistence of two adjacent phases of different diamagnetic susceptibility-i.e., mineralized bone and water in the marrow spaces. Structural analyses performed by means of NMR microscopy and digital image processing indicated that the variation in R'2
is closely related to the trabecular microstructure. Mean trabecular plate density measured along the direction of the magnetic field was found to play a major role in predicting R'2
(r = 0.74; P < 0.0001). This behavior was confirmed when the plate density was varied in individual specimens, which was achieved by rotating the specimen, making use of the bone's structural anisotropy. It is concluded that the NMR transverse relaxation rate in human cancellous bone of the spine is significantly determined by trabecular structural parameters relevant to biomechanical strength. The results further underscore the important role played by the transverse trabeculae in contributing to cancellous bone strength. The work has implications on possible in vivo use of quantitative magnetic resonance for the assessment of fracture risk in osteoporotic patients.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8234285</pmid><doi>10.1073/pnas.90.21.10250</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anatomy & physiology Biological and medical sciences Bone and Bones - anatomy & histology Bone and Bones - physiology Bone density Bone marrow Bone Marrow - anatomy & histology Bone strength Bones Density Elasticity Humans Inhomogeneity Investigative techniques, diagnostic techniques (general aspects) Lumbar Vertebrae - anatomy & histology Lumbar Vertebrae - physiology Magnetic fields Magnetic Resonance Spectroscopy - methods Male Medical sciences Middle Aged Models, Biological NMR Nuclear magnetic resonance Osteoarticular system. Muscles Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pixels Skeletal system Space life sciences Specimens Tensile Strength Youngs modulus |
| title | Relationship Between NMR Transverse Relaxation, Trabecular Bone Architecture, and Strength |
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