Mechanism of Mitotic Block and Inhibition of Cell Proliferation by Taxol at Low Concentrations

Taxol inhibited HeLa cell proliferation by inducing a sustained mitotic block at the metaphase/anaphase boundary. Half-maximal inhibition of cell proliferation occurred at 8 nM taxol, and mitosis was half-maximally blocked at 8 nM taxol. Inhibition of mitosis was associated with formation of an inco...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-10, Vol.90 (20), p.9552-9556
Hauptverfasser:	Jordan, Mary Ann, Toso, Robert J., Thrower, Doug, Wilson, Leslie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotics Antineoplastic agents Biological and medical sciences Brain Cattle Cell division Cell Division - drug effects Cell growth Cellular biology Dose-Response Relationship, Drug Drugs Fluorescent Antibody Technique General aspects HeLa Cells Humans In Vitro Techniques Interphase Low concentrations Medical sciences Metaphase Microtubules Microtubules - chemistry Microtubules - drug effects Mitosis Mitosis - drug effects Mitotic spindle apparatus Paclitaxel - administration & dosage Pharmacology. Drug treatments Polymers Spindle Apparatus - drug effects Spindle Apparatus - ultrastructure
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