Control of Dorsoventral Patterning of Somitic Derivatives by Notochord and Floor Plate
We have examined the effect of implantation of a supernumerary notochord or floor plate on dorsoventral somitic organization. We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives-i.e., axial muscles and dermis-thus converting the entire som...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-06, Vol.90 (11), p.5242-5246 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Pourquie, Olivier Coltey, Monique Teillet, Marie-Aimee Ordahl, Charles Le Douarin, Nicole M. |
| description | We have examined the effect of implantation of a supernumerary notochord or floor plate on dorsoventral somitic organization. We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives-i.e., axial muscles and dermis-thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures. |
| doi_str_mv | 10.1073/pnas.90.11.5242 |
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We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives-i.e., axial muscles and dermis-thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.11.5242</identifier><identifier>PMID: 8506372</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biological and medical sciences ; Cartilage ; Cellular differentiation ; Chick Embryo ; Dermis ; Developmental biology ; Embryo, Nonmammalian - physiology ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development ; Embryonic structures ; Embryos ; Experimental organogenesis ; Fetal Tissue Transplantation ; Fundamental and applied biological sciences. Psychology ; Mesoderm ; Monoclonal antibodies ; Muscular system ; Nervous System - cytology ; Nervous System - embryology ; Neurons ; Notochord - cytology ; Notochord - physiology ; Notochord - transplantation ; Organogenesis. 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We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives-i.e., axial muscles and dermis-thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cartilage</subject><subject>Cellular differentiation</subject><subject>Chick Embryo</subject><subject>Dermis</subject><subject>Developmental biology</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development</subject><subject>Embryonic structures</subject><subject>Embryos</subject><subject>Experimental organogenesis</subject><subject>Fetal Tissue Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mesoderm</subject><subject>Monoclonal antibodies</subject><subject>Muscular system</subject><subject>Nervous System - cytology</subject><subject>Nervous System - embryology</subject><subject>Neurons</subject><subject>Notochord - cytology</subject><subject>Notochord - physiology</subject><subject>Notochord - transplantation</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Physical growth</subject><subject>Quail</subject><subject>Tissue grafting</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EKkvhzAVQhCo4ZWs7iR1LXNC2BaQKKvFxtRxn3Hrljbe2s6L_PY42rCgHOFmj93vjmXkIPSd4STCvTreDikuRC7JsaE0foAXBgpSsFvghWmBMednWtH6MnsS4xhiLpsVH6KhtMKs4XaAfKz-k4F3hTXHmQ_Q7yLVyxZVKCcJgh-tJ-uo3NlldnEGwO5XsDmLR3RWfffL6xoe-UENfXDjvQ3HlVIKn6JFRLsKz-T1G3y_Ov60-lpdfPnxavb8sNSNNKlvGgRAQtOkaQfpesFr1jAvoSEu15tADE8YApdyoCjptMko1hZryqjK8Okbv9n23Y7eBXu-Hl9tgNyrcSa-svK8M9kZe-52sGRM029_M9uBvR4hJbmzU4JwawI9R8oZz1rb_BwljVcMbnMHXf4FrP4Yh30BSTHJClE3dTveQDj7GAOYwMMFyilVOsUqRCyKnWLPj5Z97Hvg5x6yfzLqKWjkT1KBtPGB1W9W0JRl7NWNT_9_qvX_e_hOQZnQuwc-UyRd7ch2TDweUViyviKtfsWTNYA</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Pourquie, Olivier</creator><creator>Coltey, Monique</creator><creator>Teillet, Marie-Aimee</creator><creator>Ordahl, Charles</creator><creator>Le Douarin, Nicole M.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930601</creationdate><title>Control of Dorsoventral Patterning of Somitic Derivatives by Notochord and Floor Plate</title><author>Pourquie, Olivier ; Coltey, Monique ; Teillet, Marie-Aimee ; Ordahl, Charles ; Le Douarin, Nicole M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-867e11e925b591dd964ad679eb182cc7ede69ffe227fa3ebcf9252c2e42733f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cartilage</topic><topic>Cellular differentiation</topic><topic>Chick Embryo</topic><topic>Dermis</topic><topic>Developmental biology</topic><topic>Embryo, Nonmammalian - physiology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development</topic><topic>Embryonic structures</topic><topic>Embryos</topic><topic>Experimental organogenesis</topic><topic>Fetal Tissue Transplantation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mesoderm</topic><topic>Monoclonal antibodies</topic><topic>Muscular system</topic><topic>Nervous System - cytology</topic><topic>Nervous System - embryology</topic><topic>Neurons</topic><topic>Notochord - cytology</topic><topic>Notochord - physiology</topic><topic>Notochord - transplantation</topic><topic>Organogenesis. 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We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives-i.e., axial muscles and dermis-thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8506372</pmid><doi>10.1073/pnas.90.11.5242</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Cartilage Cellular differentiation Chick Embryo Dermis Developmental biology Embryo, Nonmammalian - physiology Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development Embryonic structures Embryos Experimental organogenesis Fetal Tissue Transplantation Fundamental and applied biological sciences. Psychology Mesoderm Monoclonal antibodies Muscular system Nervous System - cytology Nervous System - embryology Neurons Notochord - cytology Notochord - physiology Notochord - transplantation Organogenesis. Physiological fonctions Physical growth Quail Tissue grafting |
| title | Control of Dorsoventral Patterning of Somitic Derivatives by Notochord and Floor Plate |
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