Extensive Genetic Diversity in the HLA Class II Region of Africans, with a Focally Predominant Allele, DRB11304

Molecular HLA class II typing of >1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in norther...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-03, Vol.89 (6), p.2277-2281
Hauptverfasser:	Adrian V. S. Hill, Catherine E. M. Allsopp, Kwiatkowski, Dominic, Taylor, Terrie E., Simon N. R. Yates, Anstey, Nicholas M., Wirima, Jack J., Brewster, David R., McMichael, Andrew J., Molyneux, Malcom E., Greenwood, Brian M.
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Alleles Biological and medical sciences Cellular biology DNA - blood DNA - isolation & purification Fundamental and applied biological sciences. Psychology Gambia Gene Frequency Genes, MHC Class II Genetic diversity Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Haplotypes High frequencies Histocompatibility Antigens Class II - genetics HLA antigens HLA-DR Antigens - genetics HLA-DRB1 Chains Homozygote Human Humans Leukocytes - immunology Malaria Medical genetics Medical research Molecules Oligonucleotides Polymorphism, Restriction Fragment Length Population genetics Population genetics, reproduction patterns Restriction Mapping White people
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