Human Herpesvirus 7 is a T-Lymphotropic Virus and is Related to, but Significantly Different from, Human Herpesvirus 6 and Human Cytomegalovirus
An independent strain (JI) of human herpesvirus 7 (HHV-7) was isolated from a patient with chronic fatigue syndrome (CFS). No significant association could be established by seroepidemiology between HHV-7 and CFS. HHV-7 is a T-lymphotropic virus, infecting CD4+and CD8+primary lymphocytes. HHV-7 can...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1992-11, Vol.89 (21), p.10552-10556 |
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| creator | Berneman, Zwi N. Ablashi, Dharam V. Li, Ge Eger-Fletcher, Maureen Reitz, Marvin S. Hung, Chia-Ling Brus, Irena Komaroff, Anthony L. Gallo, Robert C. |
| description | An independent strain (JI) of human herpesvirus 7 (HHV-7) was isolated from a patient with chronic fatigue syndrome (CFS). No significant association could be established by seroepidemiology between HHV-7 and CFS. HHV-7 is a T-lymphotropic virus, infecting CD4+and CD8+primary lymphocytes. HHV-7 can also infect SUP-T1, an immature T-cell line, with variable success. Southern blot analysis with DNA probes scanning 58.8% of the human herpesvirus 6 (HHV-6) genome and hybridizing to all HHV-6 strains tested so far revealed homology to HHV-7 with only 37.4% of the total probe length. HHV-7 contains the GGGTTA repetitive sequence, as do HHV-6 and Marek's disease chicken herpesvirus. DNA sequencing of a 186-base-pair fragment of HHV-7(JI) revealed an identity with HHV-6 and human cytomegalovirus of 57.5% and 36%, respectively. Oligonucleotide primers derived from this sequence (HV7/HV8, HV10/HV11) amplified HHV-7 DNA only and did not amplify DNA from other human herpesviruses, including 12 different HHV-6 strains. Southern blot analysis with the p43L3 probe containing the 186-base-pair HHV-7 DNA fragment hybridized to HHV-7 DNA only. The molecular divergence between human cytomegalovirus, on the one hand, and HHV-6 and HHV-7, on the other, is greater than between HHV-6 and HHV-7, which, in turn, is greater than the difference between HHV-6 strains. This study supports the classification of HHV-7 as an additional member of the human β-herpesviruses. |
| doi_str_mv | 10.1073/pnas.89.21.10552 |
| format | Article |
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No significant association could be established by seroepidemiology between HHV-7 and CFS. HHV-7 is a T-lymphotropic virus, infecting CD4+and CD8+primary lymphocytes. HHV-7 can also infect SUP-T1, an immature T-cell line, with variable success. Southern blot analysis with DNA probes scanning 58.8% of the human herpesvirus 6 (HHV-6) genome and hybridizing to all HHV-6 strains tested so far revealed homology to HHV-7 with only 37.4% of the total probe length. HHV-7 contains the GGGTTA repetitive sequence, as do HHV-6 and Marek's disease chicken herpesvirus. DNA sequencing of a 186-base-pair fragment of HHV-7(JI) revealed an identity with HHV-6 and human cytomegalovirus of 57.5% and 36%, respectively. Oligonucleotide primers derived from this sequence (HV7/HV8, HV10/HV11) amplified HHV-7 DNA only and did not amplify DNA from other human herpesviruses, including 12 different HHV-6 strains. Southern blot analysis with the p43L3 probe containing the 186-base-pair HHV-7 DNA fragment hybridized to HHV-7 DNA only. The molecular divergence between human cytomegalovirus, on the one hand, and HHV-6 and HHV-7, on the other, is greater than between HHV-6 and HHV-7, which, in turn, is greater than the difference between HHV-6 strains. This study supports the classification of HHV-7 as an additional member of the human β-herpesviruses.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.89.21.10552</identifier><identifier>PMID: 1332051</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Blotting, Southern ; CD4 Antigens - immunology ; CD8 Antigens - immunology ; Cell Line ; Cell lines ; Chronic fatigue syndrome ; Cloning, Molecular ; Cytomegalovirus - classification ; Cytomegalovirus - genetics ; DNA ; DNA Probes ; DNA, Viral - genetics ; Fluorescent antibody techniques ; Fundamental and applied biological sciences. Psychology ; Genetics ; Herpes viruses ; Herpesvirus 6, Human - classification ; Herpesvirus 6, Human - genetics ; Herpesvirus 7, Human - classification ; Herpesvirus 7, Human - genetics ; Human herpesvirus 6 ; Human herpesvirus 7 ; Humans ; Lymphatic system ; Medical research ; Microbiology ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Polymerase chain reaction ; Polymerase Chain Reaction - methods ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; T lymphocytes ; T-Lymphocytes - microbiology ; Virology ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1992-11, Vol.89 (21), p.10552-10556</ispartof><rights>Copyright 1992 The National Academy of Sciences of the United States of America</rights><rights>1993 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Nov 1, 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-962276919bbd5e16540a70d6554d1a02ad9efa72159ab3555e6eee7ea45c7db43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/89/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2360648$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2360648$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4486709$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1332051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berneman, Zwi N.</creatorcontrib><creatorcontrib>Ablashi, Dharam V.</creatorcontrib><creatorcontrib>Li, Ge</creatorcontrib><creatorcontrib>Eger-Fletcher, Maureen</creatorcontrib><creatorcontrib>Reitz, Marvin S.</creatorcontrib><creatorcontrib>Hung, Chia-Ling</creatorcontrib><creatorcontrib>Brus, Irena</creatorcontrib><creatorcontrib>Komaroff, Anthony L.</creatorcontrib><creatorcontrib>Gallo, Robert C.</creatorcontrib><title>Human Herpesvirus 7 is a T-Lymphotropic Virus and is Related to, but Significantly Different from, Human Herpesvirus 6 and Human Cytomegalovirus</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>An independent strain (JI) of human herpesvirus 7 (HHV-7) was isolated from a patient with chronic fatigue syndrome (CFS). No significant association could be established by seroepidemiology between HHV-7 and CFS. HHV-7 is a T-lymphotropic virus, infecting CD4+and CD8+primary lymphocytes. HHV-7 can also infect SUP-T1, an immature T-cell line, with variable success. Southern blot analysis with DNA probes scanning 58.8% of the human herpesvirus 6 (HHV-6) genome and hybridizing to all HHV-6 strains tested so far revealed homology to HHV-7 with only 37.4% of the total probe length. HHV-7 contains the GGGTTA repetitive sequence, as do HHV-6 and Marek's disease chicken herpesvirus. DNA sequencing of a 186-base-pair fragment of HHV-7(JI) revealed an identity with HHV-6 and human cytomegalovirus of 57.5% and 36%, respectively. Oligonucleotide primers derived from this sequence (HV7/HV8, HV10/HV11) amplified HHV-7 DNA only and did not amplify DNA from other human herpesviruses, including 12 different HHV-6 strains. Southern blot analysis with the p43L3 probe containing the 186-base-pair HHV-7 DNA fragment hybridized to HHV-7 DNA only. The molecular divergence between human cytomegalovirus, on the one hand, and HHV-6 and HHV-7, on the other, is greater than between HHV-6 and HHV-7, which, in turn, is greater than the difference between HHV-6 strains. This study supports the classification of HHV-7 as an additional member of the human β-herpesviruses.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>CD4 Antigens - immunology</subject><subject>CD8 Antigens - immunology</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Chronic fatigue syndrome</subject><subject>Cloning, Molecular</subject><subject>Cytomegalovirus - classification</subject><subject>Cytomegalovirus - genetics</subject><subject>DNA</subject><subject>DNA Probes</subject><subject>DNA, Viral - genetics</subject><subject>Fluorescent antibody techniques</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Herpes viruses</subject><subject>Herpesvirus 6, Human - classification</subject><subject>Herpesvirus 6, Human - genetics</subject><subject>Herpesvirus 7, Human - classification</subject><subject>Herpesvirus 7, Human - genetics</subject><subject>Human herpesvirus 6</subject><subject>Human herpesvirus 7</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Medical research</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Oligodeoxyribonucleotides</subject><subject>Polymerase chain reaction</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - microbiology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoso67p674ViEBEvtuNJmo8GvJHxY4QBQVdvQ9qmsxnappuki_Mv_MlmPhxdBb0Kyfu855wc3ix7iGGGQRQvx0GHWSlnBKc7Y-RWdopB4pxTCbezUwAi8pISeje7F8IaACQr4SQ7wUVBgOHT7Pti6vWAFsaPJlxbPwUkkA1Io4t8uenHSxe9G22Nvu40PTRb9ZPpdDQNiu4cVVNEn-1qsK2t9RC7DXpj29Z4M0TUetefo79b8F2h_ft8E11vVrpzO-1-dqfVXTAPDudZ9uXd24v5Il9-fP9h_nqZ14zRmEtOiOASy6pqmMGcUdACGp7EBmsgupGm1YJgJnVVMMYMN8YIoymrRVPR4ix7ta87TlVvmjqN63WnRm977TfKaatuKoO9VCt3rRgUQiT784Pdu6vJhKh6G2rTdXowbgpKpAWLgrP_gpgXFGgJCXz6B7h2kx_SDhQBTHBZAEkQ7KHauxC8aY8DY1DbRKhtIlQpFcFql4hkefz7R38Z9hFI-rODrkOtu9brobbhiFFacgEyYU8O2LbBT_Vmoxf_JlQ7dV0032JCH-3RdYjOH1lScOC0LH4APFniKg</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Berneman, Zwi N.</creator><creator>Ablashi, Dharam V.</creator><creator>Li, Ge</creator><creator>Eger-Fletcher, Maureen</creator><creator>Reitz, Marvin S.</creator><creator>Hung, Chia-Ling</creator><creator>Brus, Irena</creator><creator>Komaroff, Anthony L.</creator><creator>Gallo, Robert C.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19921101</creationdate><title>Human Herpesvirus 7 is a T-Lymphotropic Virus and is Related to, but Significantly Different from, Human Herpesvirus 6 and Human Cytomegalovirus</title><author>Berneman, Zwi N. ; Ablashi, Dharam V. ; Li, Ge ; Eger-Fletcher, Maureen ; Reitz, Marvin S. ; Hung, Chia-Ling ; Brus, Irena ; Komaroff, Anthony L. ; Gallo, Robert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-962276919bbd5e16540a70d6554d1a02ad9efa72159ab3555e6eee7ea45c7db43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>CD4 Antigens - immunology</topic><topic>CD8 Antigens - immunology</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Chronic fatigue syndrome</topic><topic>Cloning, Molecular</topic><topic>Cytomegalovirus - classification</topic><topic>Cytomegalovirus - genetics</topic><topic>DNA</topic><topic>DNA Probes</topic><topic>DNA, Viral - genetics</topic><topic>Fluorescent antibody techniques</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Herpes viruses</topic><topic>Herpesvirus 6, Human - classification</topic><topic>Herpesvirus 6, Human - genetics</topic><topic>Herpesvirus 7, Human - classification</topic><topic>Herpesvirus 7, Human - genetics</topic><topic>Human herpesvirus 6</topic><topic>Human herpesvirus 7</topic><topic>Humans</topic><topic>Lymphatic system</topic><topic>Medical research</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Oligodeoxyribonucleotides</topic><topic>Polymerase chain reaction</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - microbiology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berneman, Zwi N.</creatorcontrib><creatorcontrib>Ablashi, Dharam V.</creatorcontrib><creatorcontrib>Li, Ge</creatorcontrib><creatorcontrib>Eger-Fletcher, Maureen</creatorcontrib><creatorcontrib>Reitz, Marvin S.</creatorcontrib><creatorcontrib>Hung, Chia-Ling</creatorcontrib><creatorcontrib>Brus, Irena</creatorcontrib><creatorcontrib>Komaroff, Anthony L.</creatorcontrib><creatorcontrib>Gallo, Robert C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berneman, Zwi N.</au><au>Ablashi, Dharam V.</au><au>Li, Ge</au><au>Eger-Fletcher, Maureen</au><au>Reitz, Marvin S.</au><au>Hung, Chia-Ling</au><au>Brus, Irena</au><au>Komaroff, Anthony L.</au><au>Gallo, Robert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Herpesvirus 7 is a T-Lymphotropic Virus and is Related to, but Significantly Different from, Human Herpesvirus 6 and Human Cytomegalovirus</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>89</volume><issue>21</issue><spage>10552</spage><epage>10556</epage><pages>10552-10556</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>An independent strain (JI) of human herpesvirus 7 (HHV-7) was isolated from a patient with chronic fatigue syndrome (CFS). No significant association could be established by seroepidemiology between HHV-7 and CFS. HHV-7 is a T-lymphotropic virus, infecting CD4+and CD8+primary lymphocytes. HHV-7 can also infect SUP-T1, an immature T-cell line, with variable success. Southern blot analysis with DNA probes scanning 58.8% of the human herpesvirus 6 (HHV-6) genome and hybridizing to all HHV-6 strains tested so far revealed homology to HHV-7 with only 37.4% of the total probe length. HHV-7 contains the GGGTTA repetitive sequence, as do HHV-6 and Marek's disease chicken herpesvirus. DNA sequencing of a 186-base-pair fragment of HHV-7(JI) revealed an identity with HHV-6 and human cytomegalovirus of 57.5% and 36%, respectively. Oligonucleotide primers derived from this sequence (HV7/HV8, HV10/HV11) amplified HHV-7 DNA only and did not amplify DNA from other human herpesviruses, including 12 different HHV-6 strains. Southern blot analysis with the p43L3 probe containing the 186-base-pair HHV-7 DNA fragment hybridized to HHV-7 DNA only. The molecular divergence between human cytomegalovirus, on the one hand, and HHV-6 and HHV-7, on the other, is greater than between HHV-6 and HHV-7, which, in turn, is greater than the difference between HHV-6 strains. This study supports the classification of HHV-7 as an additional member of the human β-herpesviruses.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>1332051</pmid><doi>10.1073/pnas.89.21.10552</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1992-11, Vol.89 (21), p.10552-10556 |
| issn | 0027-8424 1091-6490 |
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| source | JSTOR Archive Collection A-Z Listing; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Base Sequence Biological and medical sciences Blotting, Southern CD4 Antigens - immunology CD8 Antigens - immunology Cell Line Cell lines Chronic fatigue syndrome Cloning, Molecular Cytomegalovirus - classification Cytomegalovirus - genetics DNA DNA Probes DNA, Viral - genetics Fluorescent antibody techniques Fundamental and applied biological sciences. Psychology Genetics Herpes viruses Herpesvirus 6, Human - classification Herpesvirus 6, Human - genetics Herpesvirus 7, Human - classification Herpesvirus 7, Human - genetics Human herpesvirus 6 Human herpesvirus 7 Humans Lymphatic system Medical research Microbiology Molecular Sequence Data Oligodeoxyribonucleotides Polymerase chain reaction Polymerase Chain Reaction - methods Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid T lymphocytes T-Lymphocytes - microbiology Virology Viruses |
| title | Human Herpesvirus 7 is a T-Lymphotropic Virus and is Related to, but Significantly Different from, Human Herpesvirus 6 and Human Cytomegalovirus |
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