Different Receptor Mechanisms Mediate the Pyrogenic and Behavioral Effects of Interleukin 1

Interleukin 1 (IL-1) is a cytokine released during immune activation that mediates the host's response to infection and inflammation. Peripheral and central injections of IL-1 induce fever and sickness behavior, including decreased food motivation and reduced interest in social activities. To d...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-10, Vol.89 (19), p.9117-9120
Hauptverfasser:	Kent, Stephen, Bluthe, Rose-Marie, Dantzer, Robert, Hardwick, Anthea J., Kelley, Keith W., Rothwell, Nancy J., Vannice, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animal behavior Animals Biological and medical sciences Body Temperature Regulation - drug effects Cerebral Ventricles - drug effects Cerebral Ventricles - physiology Cytokines Dosage Exploratory Behavior - drug effects Feeding Behavior - drug effects Fever Fundamental and applied biological sciences. Psychology Fundamental immunology Human resources Immunobiology Infections Injections, Intraperitoneal Injections, Intraventricular interleukin 1 Interleukin 1 Receptor Antagonist Protein Interleukin-1 - administration & dosage Interleukin-1 - pharmacology Interleukins Life Sciences Lymphokines, interleukins ( function, expression) Male mechanisms Mice Neurology Oxygen Consumption - drug effects Pretreatment Proteins pyrogenicity pyrogens Pyrogens - administration & dosage Pyrogens - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Receptors Receptors, Interleukin-1 - drug effects Receptors, Interleukin-1 - physiology Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Regulatory factors and their cellular receptors Rodents Routes of administration Sialoglycoproteins - administration & dosage Sialoglycoproteins - pharmacology Thermogenesis
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