Triple-Helix Formation by Oligonucleotides Containing the Three Bases Thymine, Cytosine, and Guanine

A homopurine·homopyrimidine sequence of human immunodeficiency virus (HIV) proviral DNA was chosen as a target for triple-helix-forming oligonucleotides. An oligonucleotide containing three bases (thymine, cytosine, and guanine) was shown to bind to its target sequence under physiological conditions...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-09, Vol.89 (18), p.8631-8635
Hauptverfasser:	Giovannangeli, Carine, Rougee, Michel, Garestier, Therese, Thuong, Nguyen T., Helene, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Analytical, structural and metabolic biochemistry Base Sequence Biochemistry Biological and medical sciences Chemical bases Cross-Linking Reagents Cytosine - chemistry Deoxyribonucleic acid DNA Dna, deoxyribonucleoproteins DNA, Viral - chemistry Enzymes Fundamental and applied biological sciences. Psychology Furocoumarins - chemistry Genomes Guanine - chemistry HIV HIV - genetics human immunodeficiency virus Hydrogen Bonding Irradiation Melting Molecular Sequence Data Nucleic Acid Conformation Nucleic acids Oligodeoxyribonucleotides - chemistry Oligonucleotides Plasmids Proteins Psoralens Structure-Activity Relationship Thymine - chemistry
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