Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia
The P210bcr/ablprotein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/ablinto murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transfer...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1991-12, Vol.88 (24), p.11335-11338 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | DALEY, G. Q.K VAN ETTEN, R. A BALTIMORE, D |
| description | The P210bcr/ablprotein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/ablinto murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transferred the leukemic clone to syngeneic animals, albeit with surprising inefficiency, and have observed CML and clonally related acute leukemias of lymphoid or myeloid phenotype in some transplant recipients. These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease. |
| doi_str_mv | 10.1073/pnas.88.24.11335 |
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These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.88.24.11335</identifier><identifier>PMID: 1763047</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biological and medical sciences ; Blast Crisis - genetics ; Blast Crisis - pathology ; Bone marrow ; Bone Marrow Transplantation ; Cell physiology ; Chronic myeloid leukemia ; DNA, Neoplasm - genetics ; DNA, Neoplasm - isolation & purification ; Fundamental and applied biological sciences. Psychology ; Fusion Proteins, bcr-abl - genetics ; Humans ; Leukemia ; Leukemia, Experimental - genetics ; Leukemia, Experimental - pathology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology ; Mice ; Mice, Inbred BALB C ; Molecular and cellular biology ; Neoplasm Transplantation ; Restriction Mapping ; Retroviridae - genetics ; Spleen cells ; Stem cells ; Transfection ; Transplantation ; Tumors ; Viral diseases</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1991-12, Vol.88 (24), p.11335-11338</ispartof><rights>Copyright 1991 The National Academy of Sciences of the United States of America</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-4c8e356b0cac0dd2f9a65dc926428de680ae82817c80a6110d239f993edae1103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/88/24.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2359239$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2359239$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5226000$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1763047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DALEY, G. Q.K</creatorcontrib><creatorcontrib>VAN ETTEN, R. A</creatorcontrib><creatorcontrib>BALTIMORE, D</creatorcontrib><title>Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The P210bcr/ablprotein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/ablinto murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transferred the leukemic clone to syngeneic animals, albeit with surprising inefficiency, and have observed CML and clonally related acute leukemias of lymphoid or myeloid phenotype in some transplant recipients. These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blast Crisis - genetics</subject><subject>Blast Crisis - pathology</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Cell physiology</subject><subject>Chronic myeloid leukemia</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fusion Proteins, bcr-abl - genetics</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Experimental - genetics</subject><subject>Leukemia, Experimental - pathology</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular and cellular biology</subject><subject>Neoplasm Transplantation</subject><subject>Restriction Mapping</subject><subject>Retroviridae - genetics</subject><subject>Spleen cells</subject><subject>Stem cells</subject><subject>Transfection</subject><subject>Transplantation</subject><subject>Tumors</subject><subject>Viral diseases</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQhS0EKmnhzgGEDxXismFs73ptCSGViAJSIi5wtlzvbOvirIO9i9p_j0PSQC9w8ljvezMeP0KeMZgzaMWbzWDzXKk5r-eMCdE8IDMGmlWy1vCQzAB4W6ma14_Jcc7XAKAbBUfkiLVSQN3OyLv3weaRLpLPPlM_UEtXU_ID0lXsMNDY08VVioN3dHWLIV7iEKdMlzh9x7W3T8ij3oaMT_fnCfl2_uHr4lO1_PLx8-JsWTnJ-VjVTqFo5AU466DreK-tbDqnuay56lAqsKi4Yq0rlWQMOi50r7XAzmK5ihPydtd3M12ssXM4jMkGs0l-bdOtidab-8rgr8xl_Gkawbgu9ld7e4o_JsyjWfvsMAQ7YFnHtLzRIMsH_g9kElQtOCsg7ECXYs4J-8NbGJhtNGYbjVHK8Nr8jqZYXvy9wx_DLouin-51m50NfbKD8_mANZzLEmDBXu6x7YA79f6g1_8mTD-FMOLNWNDnO_Q6jzEdWC4aXRIQvwBHybh4</recordid><startdate>19911215</startdate><enddate>19911215</enddate><creator>DALEY, G. Q.K</creator><creator>VAN ETTEN, R. A</creator><creator>BALTIMORE, D</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19911215</creationdate><title>Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia</title><author>DALEY, G. Q.K ; VAN ETTEN, R. A ; BALTIMORE, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-4c8e356b0cac0dd2f9a65dc926428de680ae82817c80a6110d239f993edae1103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blast Crisis - genetics</topic><topic>Blast Crisis - pathology</topic><topic>Bone marrow</topic><topic>Bone Marrow Transplantation</topic><topic>Cell physiology</topic><topic>Chronic myeloid leukemia</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fusion Proteins, bcr-abl - genetics</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia, Experimental - genetics</topic><topic>Leukemia, Experimental - pathology</topic><topic>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</topic><topic>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular and cellular biology</topic><topic>Neoplasm Transplantation</topic><topic>Restriction Mapping</topic><topic>Retroviridae - genetics</topic><topic>Spleen cells</topic><topic>Stem cells</topic><topic>Transfection</topic><topic>Transplantation</topic><topic>Tumors</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DALEY, G. Q.K</creatorcontrib><creatorcontrib>VAN ETTEN, R. A</creatorcontrib><creatorcontrib>BALTIMORE, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DALEY, G. Q.K</au><au>VAN ETTEN, R. A</au><au>BALTIMORE, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1991-12-15</date><risdate>1991</risdate><volume>88</volume><issue>24</issue><spage>11335</spage><epage>11338</epage><pages>11335-11338</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The P210bcr/ablprotein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/ablinto murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transferred the leukemic clone to syngeneic animals, albeit with surprising inefficiency, and have observed CML and clonally related acute leukemias of lymphoid or myeloid phenotype in some transplant recipients. These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>1763047</pmid><doi>10.1073/pnas.88.24.11335</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Blast Crisis - genetics Blast Crisis - pathology Bone marrow Bone Marrow Transplantation Cell physiology Chronic myeloid leukemia DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Fundamental and applied biological sciences. Psychology Fusion Proteins, bcr-abl - genetics Humans Leukemia Leukemia, Experimental - genetics Leukemia, Experimental - pathology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Mice Mice, Inbred BALB C Molecular and cellular biology Neoplasm Transplantation Restriction Mapping Retroviridae - genetics Spleen cells Stem cells Transfection Transplantation Tumors Viral diseases |
| title | Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia |
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