Attenuation of Focal Cerebral Ischemic Injury in Transgenic Mice Overexpressing CuZn Superoxide Dismutase

Oxygen-derived free radicals have been implicated in the pathogenesis of vasogenic edema and infarction caused by ischemia and reperfusion injury. In earlier studies, exogenously supplied liposome-entrapped CuZn superoxide dismutase (CuZn-SOD) ameliorated ischemic brain edema and infarction in rats...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-12, Vol.88 (24), p.11158-11162
Hauptverfasser:	KINOUCHI, H, EPSTEIN, C. J, MIZUI, T, CARLSON, E, CHEN, S. F, CHAN, P. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ascorbic acid Ascorbic Acid - analysis Biological and medical sciences Body Water - physiology Brain - physiopathology Brain Chemistry Brain edema Brain ischemia Cell physiology Cerebral cortex Cerebral Cortex - chemistry Cerebral Cortex - pathology Cerebral hemispheres Cerebral Infarction - pathology Cerebral Infarction - physiopathology Free radicals Fundamental and applied biological sciences. Psychology glutathione Glutathione - analysis Humans Ischemia Ischemic Attack, Transient - genetics Ischemic Attack, Transient - physiopathology Male Mice Mice, Transgenic Moisture content Molecular and cellular biology superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - physiology Superoxides Transgenic animals transgenic mice
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