Early Mutation of the neu (erbB-2) Gene During Ethylnitrosourea-Induced Oncogenesis in the Rat Schwann Cell Lineage

The development of malignant tumors of the peripheral nervous system (schwannomas) within a defined intracranial section of the rat trigeminal nerve ("trigeminal box") was used as a model to identify genetic alterations typically associated with the process of cell-lineage-specific oncogen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-11, Vol.88 (22), p.9939-9943
Hauptverfasser:	Alexander Yu. Nikitin, Leo A. P. Ballering, Lyons, John, Rajewsky, Manfred F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Base Sequence Biological and medical sciences Cell Line Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cells DNA, Neoplasm - analysis Ethylnitrosourea - pharmacology Fundamental and applied biological sciences. Psychology Genetic mutation Molecular and cellular biology Molecular Sequence Data Mutagenesis Neurilemmoma Neurilemmoma - genetics Neurilemmoma - pathology Neurons Polymerase chain reaction Polymorphism, Restriction Fragment Length Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogenes Rats Rats, Inbred Strains Receptor, ErbB-2 Schwann Cells Tumor cell line Tumors
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